Abstract
Alterations in peripheral blood lymphocyte subpopulations were examined in bovine leukosis virus (BLV)-infected cattle using antibodies specific for differentiation antigens in conjunction with analytical flow cytometry. Animals considered to be aleukemic and lymphocytotic were included in the study. Significantly fewer numbers of circulating B-lymphocytes (surface Ig-positive) and T-helper lymphocytes (BoCD4-positive) were identified in BLV-infected aleukemic cattle compared to non-infected controls while no significant differences were established for T-cytotoxic/suppressor lymphocytes (BoCD8-positive). In contrast, BLV-infected animals with persistent lymphocytosis had elevated numbers of circulating B-lymphocytes with no significant perturbation in circulating T-lymphocyte subsets identified when compared as a group with the negative control cattle. Application of regression analysis to data from individual lymphocytotic cattle demonstrated a significant correlation between absolute numbers of B- and T-lymphocytes. Increased numbers of B-lymphocytes were correlated with increased numbers of T-helper and T-cytotoxic/suppressor lymphocytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-47 |
| Number of pages | 13 |
| Journal | Veterinary Immunology and Immunopathology |
| Volume | 31 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Feb 15 1992 |
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ASJC Scopus subject areas
- Animal Science and Zoology
- Immunology
- veterinary(all)
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Alteration in lymphocyte subpopulations in bovine leukosis virus-infected cattle. / Taylor, B. C.; Stott, Jeffrey L; Thurmond, Mark; Picanso, J. P.
In: Veterinary Immunology and Immunopathology, Vol. 31, No. 1-2, 15.02.1992, p. 35-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alteration in lymphocyte subpopulations in bovine leukosis virus-infected cattle
AU - Taylor, B. C.
AU - Stott, Jeffrey L
AU - Thurmond, Mark
AU - Picanso, J. P.
PY - 1992/2/15
Y1 - 1992/2/15
N2 - Alterations in peripheral blood lymphocyte subpopulations were examined in bovine leukosis virus (BLV)-infected cattle using antibodies specific for differentiation antigens in conjunction with analytical flow cytometry. Animals considered to be aleukemic and lymphocytotic were included in the study. Significantly fewer numbers of circulating B-lymphocytes (surface Ig-positive) and T-helper lymphocytes (BoCD4-positive) were identified in BLV-infected aleukemic cattle compared to non-infected controls while no significant differences were established for T-cytotoxic/suppressor lymphocytes (BoCD8-positive). In contrast, BLV-infected animals with persistent lymphocytosis had elevated numbers of circulating B-lymphocytes with no significant perturbation in circulating T-lymphocyte subsets identified when compared as a group with the negative control cattle. Application of regression analysis to data from individual lymphocytotic cattle demonstrated a significant correlation between absolute numbers of B- and T-lymphocytes. Increased numbers of B-lymphocytes were correlated with increased numbers of T-helper and T-cytotoxic/suppressor lymphocytes.
AB - Alterations in peripheral blood lymphocyte subpopulations were examined in bovine leukosis virus (BLV)-infected cattle using antibodies specific for differentiation antigens in conjunction with analytical flow cytometry. Animals considered to be aleukemic and lymphocytotic were included in the study. Significantly fewer numbers of circulating B-lymphocytes (surface Ig-positive) and T-helper lymphocytes (BoCD4-positive) were identified in BLV-infected aleukemic cattle compared to non-infected controls while no significant differences were established for T-cytotoxic/suppressor lymphocytes (BoCD8-positive). In contrast, BLV-infected animals with persistent lymphocytosis had elevated numbers of circulating B-lymphocytes with no significant perturbation in circulating T-lymphocyte subsets identified when compared as a group with the negative control cattle. Application of regression analysis to data from individual lymphocytotic cattle demonstrated a significant correlation between absolute numbers of B- and T-lymphocytes. Increased numbers of B-lymphocytes were correlated with increased numbers of T-helper and T-cytotoxic/suppressor lymphocytes.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026586141&partnerID=8YFLogxK
U2 - 10.1016/0165-2427(92)90085-5
DO - 10.1016/0165-2427(92)90085-5
M3 - Article
C2 - 1570682
AN - SCOPUS:0026586141
VL - 31
SP - 35
EP - 47
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
SN - 0165-2427
IS - 1-2
ER -