Alteration in lymphocyte subpopulations in bovine leukosis virus-infected cattle

B. C. Taylor, Jeffrey L Stott, Mark Thurmond, J. P. Picanso

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Alterations in peripheral blood lymphocyte subpopulations were examined in bovine leukosis virus (BLV)-infected cattle using antibodies specific for differentiation antigens in conjunction with analytical flow cytometry. Animals considered to be aleukemic and lymphocytotic were included in the study. Significantly fewer numbers of circulating B-lymphocytes (surface Ig-positive) and T-helper lymphocytes (BoCD4-positive) were identified in BLV-infected aleukemic cattle compared to non-infected controls while no significant differences were established for T-cytotoxic/suppressor lymphocytes (BoCD8-positive). In contrast, BLV-infected animals with persistent lymphocytosis had elevated numbers of circulating B-lymphocytes with no significant perturbation in circulating T-lymphocyte subsets identified when compared as a group with the negative control cattle. Application of regression analysis to data from individual lymphocytotic cattle demonstrated a significant correlation between absolute numbers of B- and T-lymphocytes. Increased numbers of B-lymphocytes were correlated with increased numbers of T-helper and T-cytotoxic/suppressor lymphocytes.

Original languageEnglish (US)
Pages (from-to)35-47
Number of pages13
JournalVeterinary Immunology and Immunopathology
Volume31
Issue number1-2
DOIs
StatePublished - Feb 15 1992

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Enzootic Bovine Leukosis
enzootic bovine leukosis
Lymphocyte Subsets
B-lymphocytes
lymphocytes
Viruses
viruses
B-Lymphocytes
T-lymphocytes
cattle
Cytotoxic T-Lymphocytes
differentiation antigens
Lymphocytosis
Differentiation Antigens
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
flow cytometry
Flow Cytometry
regression analysis
Regression Analysis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Alteration in lymphocyte subpopulations in bovine leukosis virus-infected cattle. / Taylor, B. C.; Stott, Jeffrey L; Thurmond, Mark; Picanso, J. P.

In: Veterinary Immunology and Immunopathology, Vol. 31, No. 1-2, 15.02.1992, p. 35-47.

Research output: Contribution to journalArticle

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