Alpha tocopherol supplementation decreases low density lipoprotkin oxidizability in patients with diabetes hellitus

C. J. Fuller, M. Chandalia, A. Gara, I. Jialal

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetics have an increased risk of premature atherosclerosis. Since there is evidence for increased oxidizability of low density lipoprotein (LDL), this could be a crucial mechanism. The aim of the present study was to test the effect of alpha tocopherol<AT) supplementation on LDL oxidizability in patients with diabetes. 28 subjects with insulin-dependent and noninsulin-dependent diabetes (IDDM and NIDDM respectively) were randomly assigned to receive either placebo or 1200lU/d AT for 8 weeks. Plasma and LDL antioxidant concentrations and copper-catalyzed LDL oxidizability were assessed at both 0 and 8 weeks. LDL oxidation was measured by conjugated diene(CD) and lipid peroxide (LP) formation. Plasma and LDL AT were significantly increased in the AT group only. Compared to placebo, the AT group had significant reductions in LDL oxidizability as assessed by the time course curves of CD and LP formation. AT supplementation also significantly prolonged the lag phase of LDL oxidation by 41% and 45%, as shown by both CD and LP assays, respectively. There was significant positive correlations between LDL AT and the lag phase. The effects of AT on LDL oxidation were similar in both IDDM and NIDDM subjects. The results of the present study indicate that AT supplementation can be beneficial in reducing LDL oxidative susceptibility in persons with diabetes. (Research supported by the Henkel Corp. and NIH Grant M01-RR-006633).

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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