Abstract
The influence(s) of chronic injections of alpha-fetoprotein (AFP), derived from murine amniotic fluid, on the natural history of immunopathology and autoantibody production in New Zealand mice was studied and compared to analagous treatment with albumin, transferrin, or phosphate-buffered saline. Treatment of young New Zealand Black (NZB) mice with AFP, at sera levels of 60-210 μg/ml, significantly reduces the titer of IgG1, IgG2, and IgA antierythrocyte antibodies. Similarly, such treated mice have relatively normal levels of splenic Thy-1.2-bearing cells and sera immunoglobulins, at older ages, compared to control groups. In contrast, AFP has no apparent effect on the appearance of either naturally occurring thymocytotoxic antibodies (NTA) or lymphoma. Moreover, these positive features of AFP on disease were only noted for mice treated early in life; AFP had no effect when injected into older animals. Similar, but not as dramatic, changes were observed in NZB × NZW F1 hybrids. It is concluded that in pharmacologic doses, mouse amniotic fluid enriched with AFP may alter the appearance of thymic-dependent autoantibodies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 331-341 |
| Number of pages | 11 |
| Journal | Immunopharmacology |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1979 |
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Keywords
- Alpha-fetoprotein
- Autoimmunity
- New Zealand Mice
ASJC Scopus subject areas
- Pharmacology
Cite this
Alpha-fetoprotein-associated alterations of New Zealand mouse immunopathology. / Gershwin, M. Eric; Castles, James J.; Makishima, Ronald.
In: Immunopharmacology, Vol. 1, No. 4, 1979, p. 331-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alpha-fetoprotein-associated alterations of New Zealand mouse immunopathology
AU - Gershwin, M. Eric
AU - Castles, James J.
AU - Makishima, Ronald
PY - 1979
Y1 - 1979
N2 - The influence(s) of chronic injections of alpha-fetoprotein (AFP), derived from murine amniotic fluid, on the natural history of immunopathology and autoantibody production in New Zealand mice was studied and compared to analagous treatment with albumin, transferrin, or phosphate-buffered saline. Treatment of young New Zealand Black (NZB) mice with AFP, at sera levels of 60-210 μg/ml, significantly reduces the titer of IgG1, IgG2, and IgA antierythrocyte antibodies. Similarly, such treated mice have relatively normal levels of splenic Thy-1.2-bearing cells and sera immunoglobulins, at older ages, compared to control groups. In contrast, AFP has no apparent effect on the appearance of either naturally occurring thymocytotoxic antibodies (NTA) or lymphoma. Moreover, these positive features of AFP on disease were only noted for mice treated early in life; AFP had no effect when injected into older animals. Similar, but not as dramatic, changes were observed in NZB × NZW F1 hybrids. It is concluded that in pharmacologic doses, mouse amniotic fluid enriched with AFP may alter the appearance of thymic-dependent autoantibodies.
AB - The influence(s) of chronic injections of alpha-fetoprotein (AFP), derived from murine amniotic fluid, on the natural history of immunopathology and autoantibody production in New Zealand mice was studied and compared to analagous treatment with albumin, transferrin, or phosphate-buffered saline. Treatment of young New Zealand Black (NZB) mice with AFP, at sera levels of 60-210 μg/ml, significantly reduces the titer of IgG1, IgG2, and IgA antierythrocyte antibodies. Similarly, such treated mice have relatively normal levels of splenic Thy-1.2-bearing cells and sera immunoglobulins, at older ages, compared to control groups. In contrast, AFP has no apparent effect on the appearance of either naturally occurring thymocytotoxic antibodies (NTA) or lymphoma. Moreover, these positive features of AFP on disease were only noted for mice treated early in life; AFP had no effect when injected into older animals. Similar, but not as dramatic, changes were observed in NZB × NZW F1 hybrids. It is concluded that in pharmacologic doses, mouse amniotic fluid enriched with AFP may alter the appearance of thymic-dependent autoantibodies.
KW - Alpha-fetoprotein
KW - Autoimmunity
KW - New Zealand Mice
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UR - http://www.scopus.com/inward/citedby.url?scp=0018625814&partnerID=8YFLogxK
U2 - 10.1016/0162-3109(79)90030-4
DO - 10.1016/0162-3109(79)90030-4
M3 - Article
C2 - 95573
AN - SCOPUS:0018625814
VL - 1
SP - 331
EP - 341
JO - Immunopharmacology
JF - Immunopharmacology
SN - 0162-3109
IS - 4
ER -