Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12

Chia Wen Lo; Chih Sheng Chen; Ying Chi Chen; Yu An Hsu; Chi Chun Huang; Ching Yao Chang; Chao Jen Lin; Cheng Wen Lin; Hui Ju Lin; Fu-Tong Liu; Lei Wan

doi:10.1002/mnfr.201700616

Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12

Chia Wen Lo, Chih Sheng Chen, Ying Chi Chen, Yu An Hsu, Chi Chun Huang, Ching Yao Chang, Chao Jen Lin, Cheng Wen Lin, Hui Ju Lin, Fu-Tong Liu, Lei Wan

Dermatology

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.

Original language	English (US)
Article number	1700616
Journal	Molecular Nutrition and Food Research
Volume	62
Issue number	6
DOIs	https://doi.org/10.1002/mnfr.201700616
State	Published - Mar 1 2018

Keywords

3T3-L1
adipocytes
Allyl isothiocyanate
galectin-12
obesity

ASJC Scopus subject areas

Biotechnology
Food Science

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Lo, C. W., Chen, C. S., Chen, Y. C., Hsu, Y. A., Huang, C. C., Chang, C. Y., Lin, C. J., Lin, C. W., Lin, H. J., Liu, F-T., & Wan, L. (2018). Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12. Molecular Nutrition and Food Research, 62(6), [1700616]. https://doi.org/10.1002/mnfr.201700616

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title = "Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12",

abstract = "Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.",

keywords = "3T3-L1, adipocytes, Allyl isothiocyanate, galectin-12, obesity",

author = "Lo, {Chia Wen} and Chen, {Chih Sheng} and Chen, {Ying Chi} and Hsu, {Yu An} and Huang, {Chi Chun} and Chang, {Ching Yao} and Lin, {Chao Jen} and Lin, {Cheng Wen} and Lin, {Hui Ju} and Fu-Tong Liu and Lei Wan",

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AU - Lo, Chia Wen

AU - Chen, Chih Sheng

AU - Chen, Ying Chi

AU - Hsu, Yu An

AU - Huang, Chi Chun

AU - Chang, Ching Yao

AU - Lin, Chao Jen

AU - Lin, Cheng Wen

AU - Lin, Hui Ju

AU - Liu, Fu-Tong

AU - Wan, Lei

PY - 2018/3/1

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N2 - Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.

AB - Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.

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KW - Allyl isothiocyanate

KW - galectin-12

KW - obesity

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