Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12

Chia Wen Lo; Chih Sheng Chen; Ying Chi Chen; Yu An Hsu; Chi Chun Huang; Ching Yao Chang; Chao Jen Lin; Cheng Wen Lin; Hui Ju Lin; Fu-Tong Liu; Lei Wan

doi:10.1002/mnfr.201700616

Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12

Chia Wen Lo, Chih Sheng Chen, Ying Chi Chen, Yu An Hsu, Chi Chun Huang, Ching Yao Chang, Chao Jen Lin, Cheng Wen Lin, Hui Ju Lin, Fu-Tong Liu, Lei Wan

Dermatology

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8 Scopus citations

Abstract

Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.

Original language	English (US)
Article number	1700616
Journal	Molecular Nutrition and Food Research
Volume	62
Issue number	6
DOIs	https://doi.org/10.1002/mnfr.201700616
State	Published - Mar 1 2018

Keywords

3T3-L1
adipocytes
Allyl isothiocyanate
galectin-12
obesity

ASJC Scopus subject areas

Biotechnology
Food Science

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10.1002/mnfr.201700616

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Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12. / Lo, Chia Wen; Chen, Chih Sheng; Chen, Ying Chi; Hsu, Yu An; Huang, Chi Chun; Chang, Ching Yao; Lin, Chao Jen; Lin, Cheng Wen; Lin, Hui Ju; Liu, Fu-Tong; Wan, Lei.

In: Molecular Nutrition and Food Research, Vol. 62, No. 6, 1700616, 01.03.2018.

Research output: Contribution to journal › Article › peer-review

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abstract = "Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.",

keywords = "3T3-L1, adipocytes, Allyl isothiocyanate, galectin-12, obesity",

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AU - Hsu, Yu An

AU - Huang, Chi Chun

AU - Chang, Ching Yao

AU - Lin, Chao Jen

AU - Lin, Cheng Wen

AU - Lin, Hui Ju

AU - Liu, Fu-Tong

AU - Wan, Lei

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N2 - Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.

AB - Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.

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KW - Allyl isothiocyanate

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Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12

Abstract

Keywords

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