Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12

Chia Wen Lo, Chih Sheng Chen, Ying Chi Chen, Yu An Hsu, Chi Chun Huang, Ching Yao Chang, Chao Jen Lin, Cheng Wen Lin, Hui Ju Lin, Fu-Tong Liu, Lei Wan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Scope: The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. Methods and results: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by downregulating key adipogenic transcription factors. AITC influences the expression of 3T3-L1 pre-adipocytes by modulating adipokine expression (leptin and resistin) and by regulating the protein kinase B (PKB/Akt)/cAMP response element-binding protein (CREB) pathway. In HFD-fed mice, oral administration of AITC reduces the body weight, accumulation of lipid droplets in the liver, and white adipocyte size. Conclusion: In summary, the results indicate that AITC inhibits adipocyte differentiation by suppressing galectin-12 levels in 3T3L1 cells and has antiobesity effects in HFD-fed mice.

Original languageEnglish (US)
Article number1700616
JournalMolecular Nutrition and Food Research
Volume62
Issue number6
DOIs
StatePublished - Mar 1 2018

Keywords

  • 3T3-L1
  • adipocytes
  • Allyl isothiocyanate
  • galectin-12
  • obesity

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

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  • Cite this

    Lo, C. W., Chen, C. S., Chen, Y. C., Hsu, Y. A., Huang, C. C., Chang, C. Y., Lin, C. J., Lin, C. W., Lin, H. J., Liu, F-T., & Wan, L. (2018). Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12. Molecular Nutrition and Food Research, 62(6), [1700616]. https://doi.org/10.1002/mnfr.201700616