Allelic variants of Ly-5 in inbred and natural populations of mice

Michael F Seldin, Lawrence A. D'Hoostelaere, Alfred D. Steinberg, Yumiko Saga, Herbert C. Morse

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Allelic variants of Ly-5 in inbred commensal and other natural populations of mice were analyzed by patterns of restriction fragment length polymorphisms (RFLP) and Southern hybridization using an Ly-5 cDNA probe and by cell-surface staining with a panel of antibodies directed against polymorphic and nonpolymorphic Ly-5 determinants. New Ly-5 alleles were defined by RFLPs generated by both Eco RI and Bam HI restriction enzyme digests. The Mus musculus subspecies and other species within the genus Mus showed a strong correlation between allelic variants defined by restriction enzymes and serologic specificities. The data also suggest the conservation of the Ly-5 gene throughout the genus Mus.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalImmunogenetics
Volume26
Issue number1-2
DOIs
StatePublished - Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Genetics

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    Seldin, M. F., D'Hoostelaere, L. A., Steinberg, A. D., Saga, Y., & Morse, H. C. (1987). Allelic variants of Ly-5 in inbred and natural populations of mice. Immunogenetics, 26(1-2), 74-78. https://doi.org/10.1007/BF00345457