Allelic variants of Ly-5 in inbred and natural populations of mice

Michael F Seldin, Lawrence A. D'Hoostelaere, Alfred D. Steinberg, Yumiko Saga, Herbert C. Morse

Research output: Contribution to journalArticle

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Abstract

Allelic variants of Ly-5 in inbred commensal and other natural populations of mice were analyzed by patterns of restriction fragment length polymorphisms (RFLP) and Southern hybridization using an Ly-5 cDNA probe and by cell-surface staining with a panel of antibodies directed against polymorphic and nonpolymorphic Ly-5 determinants. New Ly-5 alleles were defined by RFLPs generated by both Eco RI and Bam HI restriction enzyme digests. The Mus musculus subspecies and other species within the genus Mus showed a strong correlation between allelic variants defined by restriction enzymes and serologic specificities. The data also suggest the conservation of the Ly-5 gene throughout the genus Mus.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalImmunogenetics
Volume26
Issue number1-2
DOIs
StatePublished - Jan 1987
Externally publishedYes

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Restriction Fragment Length Polymorphisms
Population
Deoxyribonuclease EcoRI
Enzymes
Complementary DNA
Alleles
Staining and Labeling
Antibodies
Genes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Seldin, M. F., D'Hoostelaere, L. A., Steinberg, A. D., Saga, Y., & Morse, H. C. (1987). Allelic variants of Ly-5 in inbred and natural populations of mice. Immunogenetics, 26(1-2), 74-78. https://doi.org/10.1007/BF00345457

Allelic variants of Ly-5 in inbred and natural populations of mice. / Seldin, Michael F; D'Hoostelaere, Lawrence A.; Steinberg, Alfred D.; Saga, Yumiko; Morse, Herbert C.

In: Immunogenetics, Vol. 26, No. 1-2, 01.1987, p. 74-78.

Research output: Contribution to journalArticle

Seldin, MF, D'Hoostelaere, LA, Steinberg, AD, Saga, Y & Morse, HC 1987, 'Allelic variants of Ly-5 in inbred and natural populations of mice', Immunogenetics, vol. 26, no. 1-2, pp. 74-78. https://doi.org/10.1007/BF00345457
Seldin, Michael F ; D'Hoostelaere, Lawrence A. ; Steinberg, Alfred D. ; Saga, Yumiko ; Morse, Herbert C. / Allelic variants of Ly-5 in inbred and natural populations of mice. In: Immunogenetics. 1987 ; Vol. 26, No. 1-2. pp. 74-78.
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