Allelic Loss of the Active X Chromosome during Bladder Carcinogenesis

Liang Cheng, Gregory T. MacLennan, Chong-Xian Pan, Timothy D. Jones, Curtiss R. Moore, Shaobo Zhang, Jian Gu, Namrata B. Patel, Chinghai Kao, Thomas A. Gardner

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Context.-Previous studies have shown that loss of the X chromosome is involved in the carcinogenesis of certain human malignancies. Objective.-To determine whether X-linked allelic losses occur during bladder tumorigenesis and whether such losses involve the active or the inactive X chromosome. Design.-We analyzed the deletion status of the X-linked human androgen receptor gene locus in 6 female patients who underwent radical cystectomies for muscle-invasive urothelial carcinoma of the urinary bladder. Four patients had coexisting urothelial carcinoma in situ. Analysis for inactivation of the X chromosome was carried out in parallel. Results.-Three cases were informative. Invasive tumor samples showed loss of heterozygosity involving the active allele at the androgen receptor locus in all 3 positive cases, whereas carcinoma in situ showed nonrandom X chromosome inactivation but not allelic deletion. Conclusions.-Our data suggest that allelic loss of the activated X chromosome is involved in bladder carcinogenesis and cancer progression.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume128
Issue number2
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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