Abstract
Chromosome arm 17p is frequently altered in a variety of human cancers, especially in breast cancer, and allelic imbalances (AIs) in the region 17p13.1 do not always coincide with mutations in the TP53 gene. A second interval that frequently shows AIs at 17p is the chromosomal band 17p13.3. This region is suspected to harbor another tumor suppressor gene. In order to get more information concerning the pattern of AIs in 17p13.3, we performed analysis of AI of 49 breast carcinomas at 6 polymorphic loci in 17p13.3. Eighty-six percent of the tumors present AI at least at one marker in 17p13.3. Among all loci tested, the highest percentage of Al was observed at loci D17S5 (77%) and D17S1528 (72%). According to these results, a minimal region of deletion could be determined between the markers D17S28 and D17S5. Fine mapping of this region revealed that the size of the deleted region is about 100-150 kb. Furthermore, a subset of the patients shows two other areas with AI close to the markers D17S1574/D17S513 and D17S849, respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-149 |
| Number of pages | 5 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 129 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Allelic imbalance and fine mapping of the 17p13.3 subregion in sporadic breast carcinomas. / Hoff, Céline; Mollenhauer, Jan; Waldau, Ben; Hamann, Ute; Poustka, Annemarie.
In: Cancer Genetics and Cytogenetics, Vol. 129, No. 2, 2001, p. 145-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Allelic imbalance and fine mapping of the 17p13.3 subregion in sporadic breast carcinomas
AU - Hoff, Céline
AU - Mollenhauer, Jan
AU - Waldau, Ben
AU - Hamann, Ute
AU - Poustka, Annemarie
PY - 2001
Y1 - 2001
N2 - Chromosome arm 17p is frequently altered in a variety of human cancers, especially in breast cancer, and allelic imbalances (AIs) in the region 17p13.1 do not always coincide with mutations in the TP53 gene. A second interval that frequently shows AIs at 17p is the chromosomal band 17p13.3. This region is suspected to harbor another tumor suppressor gene. In order to get more information concerning the pattern of AIs in 17p13.3, we performed analysis of AI of 49 breast carcinomas at 6 polymorphic loci in 17p13.3. Eighty-six percent of the tumors present AI at least at one marker in 17p13.3. Among all loci tested, the highest percentage of Al was observed at loci D17S5 (77%) and D17S1528 (72%). According to these results, a minimal region of deletion could be determined between the markers D17S28 and D17S5. Fine mapping of this region revealed that the size of the deleted region is about 100-150 kb. Furthermore, a subset of the patients shows two other areas with AI close to the markers D17S1574/D17S513 and D17S849, respectively.
AB - Chromosome arm 17p is frequently altered in a variety of human cancers, especially in breast cancer, and allelic imbalances (AIs) in the region 17p13.1 do not always coincide with mutations in the TP53 gene. A second interval that frequently shows AIs at 17p is the chromosomal band 17p13.3. This region is suspected to harbor another tumor suppressor gene. In order to get more information concerning the pattern of AIs in 17p13.3, we performed analysis of AI of 49 breast carcinomas at 6 polymorphic loci in 17p13.3. Eighty-six percent of the tumors present AI at least at one marker in 17p13.3. Among all loci tested, the highest percentage of Al was observed at loci D17S5 (77%) and D17S1528 (72%). According to these results, a minimal region of deletion could be determined between the markers D17S28 and D17S5. Fine mapping of this region revealed that the size of the deleted region is about 100-150 kb. Furthermore, a subset of the patients shows two other areas with AI close to the markers D17S1574/D17S513 and D17S849, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0034838302&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034838302&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(01)00450-2
DO - 10.1016/S0165-4608(01)00450-2
M3 - Article
C2 - 11566345
AN - SCOPUS:0034838302
VL - 129
SP - 145
EP - 149
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -