All-phase MR angiography using independent component analysis of dynamic contrast enhanced MRI time series: φ-MRA

Kiyotaka Suzuki, Hitoshi Matsuzawa, Hironaka Igarashi, Masaki Watanabe, Naoki Nakayama, Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Dynamic contrast enhanced magnetic resonance imaging (dynamic MRI) represents a MRI version of non-diffusible tracer methods, the main clinical use of which is the physiological construction of what is conventionally referred to as perfusion images. The raw data utilized for constructing MRI perfusion images are time series of pixel signal alterations associated with the passage of a gadolinium containing contrast agent. Such time series are highly compatible with independent component analysis (ICA), a novel statistical signal processing technique capable of effectively separating a single mixture of multiple signals into their original independent source signals (blind separation). Accordingly, we applied ICA to dynamic MRI time series. The technique was found to be powerful, allowing for hitherto unobtainable assessment of regional cerebral hemodynamics in vivo.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalMagnetic Resonance in Medical Sciences
Volume2
Issue number1
DOIs
StatePublished - 2003

Keywords

  • Cumulant
  • ICA
  • MRA
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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