All in the family: Proneural bHLH genes and neuronal diversity

Nicholas E. Baker, Nadean L Brown

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Proneural basic Helix-Loop-Helix (bHLH) proteins are required for neuronal determination and the differentiation of most neural precursor cells. These transcription factors are expressed in vastly divergent organisms, ranging from sponges to primates. Here, we review proneural bHLH gene evolution and function in the Drosophila and vertebrate nervous systems, arguing that the Drosophila gene atonal provides a useful platform for understanding proneural gene structure and regulation. We also discuss how functional equivalency experiments using distinct proneural genes can reveal how proneural gene duplication and divergence are interwoven with neuronal complexity.

Original languageEnglish (US)
Article numberdev159426
JournalDevelopment (Cambridge)
Volume145
Issue number9
DOIs
StatePublished - May 1 2018

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Keywords

  • bHLH gene
  • Neural development
  • Neurogenesis
  • Neuronal diversity
  • Proneural gene

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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