Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: Synthesis and photoreactivity

Heike Wulff, Heiko Rauer, Tim Düring, Christine Hanselmann, Katharina Ruff, Anja Wrisch, Stephan Grissmer, Wolfram Hänsel

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67 Scopus citations

Abstract

A series of psoralens and structurally related 5,7-disubstituted coumarins was synthesized and investigated for their K+ channel blocking activity as well as for their phototoxicity to Artemia salina and their ability to generate singlet oxygen and to photomodify DNA. After screening the compounds on Ranvier nodes of the toad Xenopus laevis, the affinities of the most promising compounds, which proved to be psoralens bearing alkoxy substituents in the 5-position or alkoxymethyl substituents in the neighboring 4- or 4'-position, to a number of homomeric K+ channels were characterized. All compounds exhibited the highest affinity to Kv1.2. 5,8- Diethoxypsoralen (10d) was found to be an equally potent inhibitor of Kv1.2 and Kv1.3, while lacking the phototoxicity normally inherent in psoralens. The reported compounds represent a novel series of nonpeptide blockers of Shaker-type K+ channels that could be further developed into selective inhibitors of Kv1.2 or Kv1.3.

Original languageEnglish (US)
Pages (from-to)4542-4549
Number of pages8
JournalJournal of Medicinal Chemistry
Volume41
Issue number23
DOIs
StatePublished - Nov 5 1998
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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    Wulff, H., Rauer, H., Düring, T., Hanselmann, C., Ruff, K., Wrisch, A., Grissmer, S., & Hänsel, W. (1998). Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: Synthesis and photoreactivity. Journal of Medicinal Chemistry, 41(23), 4542-4549. https://doi.org/10.1021/jm981032o