Alcohol intake and brain structure in a multiethnic elderly cohort

Yian Gu, Nikolaos Scarmeas, Erica Eaton Short, José A. Luchsinger, Charles DeCarli, Yaakov Stern, Jennifer J. Manly, Nicole Schupf, Richard Mayeux, Adam M. Brickman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background & aims: Evidence suggests that consuming light-to-moderate amounts of alcohol reduces the risk of dementia and is associated better cognitive function and less cardiovascular disease, relative to those consuming no or heavy alcohol. There are only minimal data on the association between alcohol and brain magnetic resonance imaging (MRI) markers. This study aimed to examine the association between alcohol and brain structure measured with MRI. Methods: In this cross-sectional study, high-resolution structural MRI was collected on 589 multi-ethnic community residents of New York aged ≥65 with available alcohol intake assessments via a food frequency questionnaire. Total brain volume (TBV), white matter hyperintensity volume (WMHV), and presence of infarcts were derived from MRI scans with established methods. We examined the association of alcohol intake with these imaging markers using regression models adjusted for demographic, clinical, and vascular risk factors. Results: Compared to non-drinking, light-to-moderate total alcohol (b=0.007, p=0.04) or wine (b=0.008, p=0.05) intake, but not beer or liquor intake, was associated with larger TBV. Further analysis showed a dose-response association between alcohol (p-trend=0.03) or wine (p-trend=0.006)and TBV. Overall, alcohol intake was not associated with WMHV or brain infarcts. Conclusions: Our study suggests that among older adults in the community, light-to-moderate alcohol intake, in particular wine, is associated with larger TBV. These findings suggest that light to moderate alcohol consumption is potentially beneficial for brain aging, but replication is needed.

Original languageEnglish (US)
Pages (from-to)662-667
Number of pages6
JournalClinical Nutrition
Issue number4
StatePublished - 2014


  • Alcohol
  • Brain atrophy
  • Cerebrovascular disease
  • Magnetic resonance imaging (MRI)
  • Neuroepidemiology
  • Nutrition

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics
  • Medicine(all)


Dive into the research topics of 'Alcohol intake and brain structure in a multiethnic elderly cohort'. Together they form a unique fingerprint.

Cite this