Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis

George Kaysen, P. Y. Schoenfeld

Research output: Contribution to journalArticle

133 Scopus citations

Abstract

Albumin and protein removal rates were studied in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). In nine patients simultaneous studies of albumin distribution and turnover were performed. Total albumin loss was 4.23 ± 1.42 g/1.73 m2/24 hr; total protein removed was 8.79 ± 4.21 g/1.73 m2/24 hr. Although these values were well within the range for severe nephrosis, serum albumin concentration remained nearly normal, 3.7 ± 0.5 g/dl. Plasma albumin mass, 120.0 ± 25.2 g/1.73 m2, and total albumin mass, 249 ± 29.1 g/1.73 m2, did not differ from those of the control group. Compared with the control group, patients had reduced albumin catabolism, 9.76 ± 1.74 g/1.73 m2/24 hr versus 13.8 ± 0.77 g/1.73 m2/24 hr (P < 0.001). Within the patient group albumin synthesis increased with increased albumin loss. Serum albumin concentration correlated negatively with albumin losses (P < 0.001). The CAPD patients maintained albumin homeostasis through decreased albumin catabolism and increased synthesis. All major albumin pools were maintained despite massive albumin loss.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalKidney International
Volume25
Issue number1
StatePublished - 1984

ASJC Scopus subject areas

  • Nephrology

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