Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis

George Kaysen, P. Y. Schoenfeld

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Albumin and protein removal rates were studied in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). In nine patients simultaneous studies of albumin distribution and turnover were performed. Total albumin loss was 4.23 ± 1.42 g/1.73 m2/24 hr; total protein removed was 8.79 ± 4.21 g/1.73 m2/24 hr. Although these values were well within the range for severe nephrosis, serum albumin concentration remained nearly normal, 3.7 ± 0.5 g/dl. Plasma albumin mass, 120.0 ± 25.2 g/1.73 m2, and total albumin mass, 249 ± 29.1 g/1.73 m2, did not differ from those of the control group. Compared with the control group, patients had reduced albumin catabolism, 9.76 ± 1.74 g/1.73 m2/24 hr versus 13.8 ± 0.77 g/1.73 m2/24 hr (P < 0.001). Within the patient group albumin synthesis increased with increased albumin loss. Serum albumin concentration correlated negatively with albumin losses (P < 0.001). The CAPD patients maintained albumin homeostasis through decreased albumin catabolism and increased synthesis. All major albumin pools were maintained despite massive albumin loss.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalKidney International
Volume25
Issue number1
StatePublished - 1984

Fingerprint

Continuous Ambulatory Peritoneal Dialysis
Albumins
Homeostasis
Serum Albumin
Nephrosis
Control Groups
Proteins

ASJC Scopus subject areas

  • Nephrology

Cite this

Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis. / Kaysen, George; Schoenfeld, P. Y.

In: Kidney International, Vol. 25, No. 1, 1984, p. 107-114.

Research output: Contribution to journalArticle

@article{eefd724593f446d584b093469874d327,
title = "Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis",
abstract = "Albumin and protein removal rates were studied in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). In nine patients simultaneous studies of albumin distribution and turnover were performed. Total albumin loss was 4.23 ± 1.42 g/1.73 m2/24 hr; total protein removed was 8.79 ± 4.21 g/1.73 m2/24 hr. Although these values were well within the range for severe nephrosis, serum albumin concentration remained nearly normal, 3.7 ± 0.5 g/dl. Plasma albumin mass, 120.0 ± 25.2 g/1.73 m2, and total albumin mass, 249 ± 29.1 g/1.73 m2, did not differ from those of the control group. Compared with the control group, patients had reduced albumin catabolism, 9.76 ± 1.74 g/1.73 m2/24 hr versus 13.8 ± 0.77 g/1.73 m2/24 hr (P < 0.001). Within the patient group albumin synthesis increased with increased albumin loss. Serum albumin concentration correlated negatively with albumin losses (P < 0.001). The CAPD patients maintained albumin homeostasis through decreased albumin catabolism and increased synthesis. All major albumin pools were maintained despite massive albumin loss.",
author = "George Kaysen and Schoenfeld, {P. Y.}",
year = "1984",
language = "English (US)",
volume = "25",
pages = "107--114",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis

AU - Kaysen, George

AU - Schoenfeld, P. Y.

PY - 1984

Y1 - 1984

N2 - Albumin and protein removal rates were studied in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). In nine patients simultaneous studies of albumin distribution and turnover were performed. Total albumin loss was 4.23 ± 1.42 g/1.73 m2/24 hr; total protein removed was 8.79 ± 4.21 g/1.73 m2/24 hr. Although these values were well within the range for severe nephrosis, serum albumin concentration remained nearly normal, 3.7 ± 0.5 g/dl. Plasma albumin mass, 120.0 ± 25.2 g/1.73 m2, and total albumin mass, 249 ± 29.1 g/1.73 m2, did not differ from those of the control group. Compared with the control group, patients had reduced albumin catabolism, 9.76 ± 1.74 g/1.73 m2/24 hr versus 13.8 ± 0.77 g/1.73 m2/24 hr (P < 0.001). Within the patient group albumin synthesis increased with increased albumin loss. Serum albumin concentration correlated negatively with albumin losses (P < 0.001). The CAPD patients maintained albumin homeostasis through decreased albumin catabolism and increased synthesis. All major albumin pools were maintained despite massive albumin loss.

AB - Albumin and protein removal rates were studied in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). In nine patients simultaneous studies of albumin distribution and turnover were performed. Total albumin loss was 4.23 ± 1.42 g/1.73 m2/24 hr; total protein removed was 8.79 ± 4.21 g/1.73 m2/24 hr. Although these values were well within the range for severe nephrosis, serum albumin concentration remained nearly normal, 3.7 ± 0.5 g/dl. Plasma albumin mass, 120.0 ± 25.2 g/1.73 m2, and total albumin mass, 249 ± 29.1 g/1.73 m2, did not differ from those of the control group. Compared with the control group, patients had reduced albumin catabolism, 9.76 ± 1.74 g/1.73 m2/24 hr versus 13.8 ± 0.77 g/1.73 m2/24 hr (P < 0.001). Within the patient group albumin synthesis increased with increased albumin loss. Serum albumin concentration correlated negatively with albumin losses (P < 0.001). The CAPD patients maintained albumin homeostasis through decreased albumin catabolism and increased synthesis. All major albumin pools were maintained despite massive albumin loss.

UR - http://www.scopus.com/inward/record.url?scp=0021319823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021319823&partnerID=8YFLogxK

M3 - Article

C2 - 6727122

AN - SCOPUS:0021319823

VL - 25

SP - 107

EP - 114

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 1

ER -