AKT regulates androgen receptor-dependent growth and psa expression in prostate cancer

Margarita Mikhailova, Yu Wang, Roble Bedolla, Xiao Hua Lu, Jeffrey I. Kreisberg, Paramita M. Ghosh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Scopus citations

Abstract

Recurrent prostate cancer (PC) is usually treated with androgen deprivation therapy, which, despite initial success, eventually fails due to the development of androgen-independent PC. Androgen deprivation stimulates a significant increase in the phosphorylation (activation) of Akt, a serine/threonine kinase, which regulates cell growth and survival. Hence, we asked whether the increase in Akt phosphorylation contributes to the development of androgen independence. Akt regulates transcriptional activity of the androgen receptor (AR), and our data show that Akt-stimulated AR transcriptional activity is dependent on androgen-binding to the AR. PC proliferation has both androgen-sensitive and insensitive components. The androgen sensitive component is Akt-dependent, while the androgen-insensitive is not. However, Akt-induced cell survival is largely AR independent, suggesting that the cell stimulates Akt phosphorylation when subjected to androgen deprivation as an alternate pathway to maintain survival.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages397-405
Number of pages9
Volume617
DOIs
StatePublished - 2008

Publication series

NameAdvances in Experimental Medicine and Biology
Volume617
ISSN (Print)00652598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Mikhailova, M., Wang, Y., Bedolla, R., Lu, X. H., Kreisberg, J. I., & Ghosh, P. M. (2008). AKT regulates androgen receptor-dependent growth and psa expression in prostate cancer. In Advances in Experimental Medicine and Biology (Vol. 617, pp. 397-405). (Advances in Experimental Medicine and Biology; Vol. 617). https://doi.org/10.1007/978-0-387-69080-3_38