Airway transplantation: A debate worth having?

Martin Birchall, Paolo Macchiarini

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Laryngeal and tracheal transplantation have been proposed as treatments for irreversible airway disease for many years. Despite much research, there has only been one true laryngeal transplant reported. Although this was in many ways a success, several barriers remain before full clinical trials. There are issues over patient selection, reinnervation, immunosuppression, and cost-benefit. For the trachea, where finely tuned neuromuscular activity is not an issue, tissue-engineering probably represents the future. This overview discusses the arguments for and against laryngeal and tracheal transplantation and suggests ways of overcoming these barriers.

Original languageEnglish (US)
Pages (from-to)1075-1080
Number of pages6
JournalTransplantation
Volume85
Issue number8
DOIs
StatePublished - Apr 2008
Externally publishedYes

Keywords

  • Laryngeal transplantation
  • Mucosal immunity
  • Reinnervation
  • Tissue engineering
  • Tracheal transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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