Airway tissue engineering

Jonathan M. Fishman, Paolo De Coppi, Martin J. Elliott, Anthony Atala, Martin A. Birchall, Paolo Macchiarini

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Prosthetic replacements, autologous tissue transfer and allografts have so far failed to offer functional solutions for the treatment of long circumferential tracheal defects and loss of a functioning larynx. Interest has therefore turned increasingly to the field of tissue-engineering which applies the principles and methods of bioengineering, material science, cell transplantation and life sciences in an effort to develop in vitro biological substitutes able to restore, maintain or improve tissue and organ function. Areas covered: This article gives an overview of the tissue-engineering approach to airway replacement and will describe the encouraging results obtained so far in tracheal regeneration. The recent advances in the field of tissue-engineering have provided a new attractive approach towards the concept of functional substitutes and may represent an alternative to the shortage of suitable grafts for reconstructive airway surgery. We summarize fundamental questions, as well as future directions in airway tissue engineering. Expert opinion: The replacement of active movement, as would be necessary to replace an entire larynx introduces another order of magnitude of complexity, although progress in this area is starting to bear fruit. In addition, the stem cell field is advancing rapidly, opening new avenues for this type of therapy.

Original languageEnglish (US)
Pages (from-to)1623-1635
Number of pages13
JournalExpert Opinion on Biological Therapy
Volume11
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

Keywords

  • angiogenesis
  • artificial organs
  • biocompatible materials
  • bioreactors
  • esophagus
  • larynx
  • regenerative medicine
  • stem cells
  • tissue engineering
  • tissue scaffolds
  • trachea
  • transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery

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  • Cite this

    Fishman, J. M., De Coppi, P., Elliott, M. J., Atala, A., Birchall, M. A., & Macchiarini, P. (2011). Airway tissue engineering. Expert Opinion on Biological Therapy, 11(12), 1623-1635. https://doi.org/10.1517/14712598.2011.623696