Air Pollution and Chronic Obstructive Airway Disease

Imre Redai, Angela Haczku

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic obstructive airway disease (COPD) is a major cause of disability, and it’s the third leading cause of death in the United States. It is a progressive condition characterized by exacerbations and remissions of coughing, mucus production, shortness of breath, wheezing, chest tightness, and other symptoms. Pathologically, COPD is manifested in emphysema and/or chronic bronchitis. The leading cause of COPD is tobacco smoking. However, emerging epidemiologic evidence suggests that long-term exposure to air pollution also contributes to the symptoms of COPD. While the disease is progressive, it develops slowly and the underlying mechanisms are unclear. This chapter investigates the role of air pollution in COPD and the cellular-molecular pathways of pollutant-caused pathological changes.

Original languageEnglish (US)
Title of host publicationMolecular and Integrative Toxicology
PublisherSpringer Science+Business Media B.V.
Pages119-149
Number of pages31
DOIs
StatePublished - 2015

Publication series

NameMolecular and Integrative Toxicology
ISSN (Print)2168-4219
ISSN (Electronic)2168-4235

Keywords

  • Apoptosis
  • Autophagy
  • COPD
  • Criteria pollutants (nitrogen oxides, sulfur oxides, particulate matter, ozone, carbon monoxide and lead) US EPA
  • Oxidative stress

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology (medical)
  • Drug Discovery
  • Toxicology

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