Air pollutants and cough

Jesse P. Joad, Shin ichi Sekizawa, Chao-Yin Chen, Ann C. Bonham

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Epidemiological studies have shown that exposure to air pollution is associated with respiratory symptoms and decreases in lung function. This paper reviews recent literature showing that exposure to particulate matter, irritant gases, environmental tobacco smoke (ETS), mixed pollutants, and molds is associated with an increase in cough and wheeze. Some pollutants, like particulate matter and mixed pollutants, appear to increase cough at least as much as wheeze. Others, like irritant gases, appear to increase wheeze more than cough. For ETS, exposure during childhood is associated with cough and wheeze in adulthood, suggesting that the pollutant permanently alters some important aspect of the lungs, immune system or nervous system. We have shown in animal studies that pollutants change the neural control of airways and cough. Second hand smoke (SHS) exposure lengthened stimulated apnoea, increased the number of stimulated coughs, and augmented the degree of stimulated bronchoconstriction. The mechanisms included enhanced reactivity of the peripheral sensory neurones and second-order neurones in the nucleus tractus solitarius (NTS). NTS effects were due to a substance P mechanism at least in part. Ozone and allergen increased the intrinsic excitability of second-order neurones in the NTS. The animal studies suggest that the cough and wheeze experienced by humans exposed to pollutants may involve plasticity in the nervous system.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalPulmonary Pharmacology and Therapeutics
Issue number4
StatePublished - Aug 2007


  • Air pollution
  • Cough
  • Environmental tobacco smoke
  • Neural pathways for cough

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology


Dive into the research topics of 'Air pollutants and cough'. Together they form a unique fingerprint.

Cite this