Air pollutant effects on fetal and early postnatal development

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Numerical research on the health effects of air pollution has been published in the last decade. Epidemiological studies have shown that children's exposure to air pollutants during fetal development and early postnatal life is associated with many types of health problems including abnormal development (low birth weight [LBW], very low birth weight [VLBW], preterm birth [PTB], intrauterine growth restriction [IUGR], congenital defects, and intrauterine and infant mortality), decreased lung growth, increased rates of respiratory tract infections, childhood asthma, behavioral problems, and neurocognitive decrements. This review focuses on the health effects of major outdoor air pollutants including particulates, carbon monoxide (CO), sulfur and nitrogen oxides (SO2, NOx), ozone, and one common indoor air pollutant, environmental tobacco smoke (ETS). Animal data is presented that demonstrate perinatal windows of susceptibility to sidestream smoke, a surrogate for ETS, resulting in altered airway sensitivity and cell type frequency. A study of neonatal monkeys exposed to sidestream smoke during the perinatal period and/or early postnatal period that resulted in an altered balance of Th1-/Th2-cytokine secretion, skewing the immune response toward the allergy-associated Th2 cytokine phenotype, is also discussed.

Original languageEnglish (US)
Pages (from-to)144-154
Number of pages11
JournalBirth Defects Research Part C - Embryo Today: Reviews
Volume81
Issue number3
DOIs
StatePublished - Sep 2007

Fingerprint

Air Pollutants
Smoke
Tobacco
Sulfur Oxides
Health
Th1-Th2 Balance
Very Low Birth Weight Infant
Particulate Matter
Ozone
Premature Birth
Air Pollution
Infant Mortality
Low Birth Weight Infant
Carbon Monoxide
Growth
Fetal Development
Respiratory Tract Infections
Haplorhini
Epidemiologic Studies
Hypersensitivity

Keywords

  • Air pollutants
  • Birth defect
  • Development
  • Environmental tobacco smoke
  • Immune system
  • Pulmonary

ASJC Scopus subject areas

  • Embryology

Cite this

Air pollutant effects on fetal and early postnatal development. / Wang, Lei; Pinkerton, Kent E.

In: Birth Defects Research Part C - Embryo Today: Reviews, Vol. 81, No. 3, 09.2007, p. 144-154.

Research output: Contribution to journalArticle

@article{fa3ac725040b491a8978336eed0f0eb8,
title = "Air pollutant effects on fetal and early postnatal development",
abstract = "Numerical research on the health effects of air pollution has been published in the last decade. Epidemiological studies have shown that children's exposure to air pollutants during fetal development and early postnatal life is associated with many types of health problems including abnormal development (low birth weight [LBW], very low birth weight [VLBW], preterm birth [PTB], intrauterine growth restriction [IUGR], congenital defects, and intrauterine and infant mortality), decreased lung growth, increased rates of respiratory tract infections, childhood asthma, behavioral problems, and neurocognitive decrements. This review focuses on the health effects of major outdoor air pollutants including particulates, carbon monoxide (CO), sulfur and nitrogen oxides (SO2, NOx), ozone, and one common indoor air pollutant, environmental tobacco smoke (ETS). Animal data is presented that demonstrate perinatal windows of susceptibility to sidestream smoke, a surrogate for ETS, resulting in altered airway sensitivity and cell type frequency. A study of neonatal monkeys exposed to sidestream smoke during the perinatal period and/or early postnatal period that resulted in an altered balance of Th1-/Th2-cytokine secretion, skewing the immune response toward the allergy-associated Th2 cytokine phenotype, is also discussed.",
keywords = "Air pollutants, Birth defect, Development, Environmental tobacco smoke, Immune system, Pulmonary",
author = "Lei Wang and Pinkerton, {Kent E}",
year = "2007",
month = "9",
doi = "10.1002/bdrc.20097",
language = "English (US)",
volume = "81",
pages = "144--154",
journal = "Birth Defects Research Part C - Embryo Today: Reviews",
issn = "1542-975X",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Air pollutant effects on fetal and early postnatal development

AU - Wang, Lei

AU - Pinkerton, Kent E

PY - 2007/9

Y1 - 2007/9

N2 - Numerical research on the health effects of air pollution has been published in the last decade. Epidemiological studies have shown that children's exposure to air pollutants during fetal development and early postnatal life is associated with many types of health problems including abnormal development (low birth weight [LBW], very low birth weight [VLBW], preterm birth [PTB], intrauterine growth restriction [IUGR], congenital defects, and intrauterine and infant mortality), decreased lung growth, increased rates of respiratory tract infections, childhood asthma, behavioral problems, and neurocognitive decrements. This review focuses on the health effects of major outdoor air pollutants including particulates, carbon monoxide (CO), sulfur and nitrogen oxides (SO2, NOx), ozone, and one common indoor air pollutant, environmental tobacco smoke (ETS). Animal data is presented that demonstrate perinatal windows of susceptibility to sidestream smoke, a surrogate for ETS, resulting in altered airway sensitivity and cell type frequency. A study of neonatal monkeys exposed to sidestream smoke during the perinatal period and/or early postnatal period that resulted in an altered balance of Th1-/Th2-cytokine secretion, skewing the immune response toward the allergy-associated Th2 cytokine phenotype, is also discussed.

AB - Numerical research on the health effects of air pollution has been published in the last decade. Epidemiological studies have shown that children's exposure to air pollutants during fetal development and early postnatal life is associated with many types of health problems including abnormal development (low birth weight [LBW], very low birth weight [VLBW], preterm birth [PTB], intrauterine growth restriction [IUGR], congenital defects, and intrauterine and infant mortality), decreased lung growth, increased rates of respiratory tract infections, childhood asthma, behavioral problems, and neurocognitive decrements. This review focuses on the health effects of major outdoor air pollutants including particulates, carbon monoxide (CO), sulfur and nitrogen oxides (SO2, NOx), ozone, and one common indoor air pollutant, environmental tobacco smoke (ETS). Animal data is presented that demonstrate perinatal windows of susceptibility to sidestream smoke, a surrogate for ETS, resulting in altered airway sensitivity and cell type frequency. A study of neonatal monkeys exposed to sidestream smoke during the perinatal period and/or early postnatal period that resulted in an altered balance of Th1-/Th2-cytokine secretion, skewing the immune response toward the allergy-associated Th2 cytokine phenotype, is also discussed.

KW - Air pollutants

KW - Birth defect

KW - Development

KW - Environmental tobacco smoke

KW - Immune system

KW - Pulmonary

UR - http://www.scopus.com/inward/record.url?scp=36048976330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36048976330&partnerID=8YFLogxK

U2 - 10.1002/bdrc.20097

DO - 10.1002/bdrc.20097

M3 - Article

C2 - 17963272

AN - SCOPUS:36048976330

VL - 81

SP - 144

EP - 154

JO - Birth Defects Research Part C - Embryo Today: Reviews

JF - Birth Defects Research Part C - Embryo Today: Reviews

SN - 1542-975X

IS - 3

ER -