AID in reprogramming: Quick and efficient

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Current methods of reprogramming differentiated cells into induced pluripotent stem cells remain slow and inefficient. In a recent report published online in Nature, Bhutani et al. [1] developed a cell fusion strategy, achieving quick and efficient reprogramming toward pluripotency. Using this assay, they identified an immune system protein called activation-induced cytidine deaminase, or AID, which unexpectedly is actually able to "aid" in reprogramming due to its involvement in DNA demethylation that is required for induction of the two key pluripotency genes, Oct4 and Nanog. More recently, Popp et al. [2] also reported online in Nature that AID is important for complete cell reprogramming in mammals. Together, these findings provide new insights into how cells are reprogrammed, identify the specific role of AID in cell fate reversal, and advance the field of regenerative medicine.

Original languageEnglish (US)
Pages (from-to)385-387
Number of pages3
JournalBioEssays
Volume32
Issue number5
DOIs
StatePublished - May 2010

Keywords

  • Activation-induced cytidine deaminase
  • Induced pluripotent stem cells
  • Pluripotency
  • Reprogramming

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'AID in reprogramming: Quick and efficient'. Together they form a unique fingerprint.

  • Cite this