AID in reprogramming

Quick and efficient

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Current methods of reprogramming differentiated cells into induced pluripotent stem cells remain slow and inefficient. In a recent report published online in Nature, Bhutani et al. [1] developed a cell fusion strategy, achieving quick and efficient reprogramming toward pluripotency. Using this assay, they identified an immune system protein called activation-induced cytidine deaminase, or AID, which unexpectedly is actually able to "aid" in reprogramming due to its involvement in DNA demethylation that is required for induction of the two key pluripotency genes, Oct4 and Nanog. More recently, Popp et al. [2] also reported online in Nature that AID is important for complete cell reprogramming in mammals. Together, these findings provide new insights into how cells are reprogrammed, identify the specific role of AID in cell fate reversal, and advance the field of regenerative medicine.

Original languageEnglish (US)
Pages (from-to)385-387
Number of pages3
JournalBioEssays
Volume32
Issue number5
DOIs
StatePublished - May 2010

Fingerprint

Mammals
Immune system
Stem cells
Assays
Fusion reactions
Genes
DNA
Induced Pluripotent Stem Cells
Proteins
Regenerative Medicine
Cell Fusion
Immune System
AICDA (activation-induced cytidine deaminase)
Cellular Reprogramming

Keywords

  • Activation-induced cytidine deaminase
  • Induced pluripotent stem cells
  • Pluripotency
  • Reprogramming

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

AID in reprogramming : Quick and efficient. / Deng, Wenbin.

In: BioEssays, Vol. 32, No. 5, 05.2010, p. 385-387.

Research output: Contribution to journalArticle

Deng, Wenbin. / AID in reprogramming : Quick and efficient. In: BioEssays. 2010 ; Vol. 32, No. 5. pp. 385-387.
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