Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin

Comparative studies in mammalian and nonmammalian species

Michael S. Denison, Christopher F. Wilkinson, Allan B. Okey

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The Ah receptor was identified and characterized in cytosol from a large number of diverse animal species. Molecular properties of the Ah receptor were similar in all species which had detectable receptor. However, subtle differences in receptor properties exist among animal species and these differences indicate that the Ah receptor protein is not identical in all species. It is not yet known whether differences in receptor properties among animal species play a significant role in determining differential susceptibility of the species to toxicity from halogenated aromatic compounds.

Original languageEnglish (US)
Pages (from-to)1665-1672
Number of pages8
JournalChemosphere
Volume15
Issue number9-12
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Aryl Hydrocarbon Receptors
dioxin
comparative study
Animals
Aromatic compounds
Cytosol
Toxicity
toxicity
Proteins
protein
animal species

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin : Comparative studies in mammalian and nonmammalian species. / Denison, Michael S.; Wilkinson, Christopher F.; Okey, Allan B.

In: Chemosphere, Vol. 15, No. 9-12, 1986, p. 1665-1672.

Research output: Contribution to journalArticle

Denison, Michael S. ; Wilkinson, Christopher F. ; Okey, Allan B. / Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin : Comparative studies in mammalian and nonmammalian species. In: Chemosphere. 1986 ; Vol. 15, No. 9-12. pp. 1665-1672.
@article{6c7ee1426aef47cab7b183c4eae4fbfa,
title = "Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species",
abstract = "The Ah receptor was identified and characterized in cytosol from a large number of diverse animal species. Molecular properties of the Ah receptor were similar in all species which had detectable receptor. However, subtle differences in receptor properties exist among animal species and these differences indicate that the Ah receptor protein is not identical in all species. It is not yet known whether differences in receptor properties among animal species play a significant role in determining differential susceptibility of the species to toxicity from halogenated aromatic compounds.",
author = "Denison, {Michael S.} and Wilkinson, {Christopher F.} and Okey, {Allan B.}",
year = "1986",
doi = "10.1016/0045-6535(86)90452-2",
language = "English (US)",
volume = "15",
pages = "1665--1672",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier Limited",
number = "9-12",

}

TY - JOUR

T1 - Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin

T2 - Comparative studies in mammalian and nonmammalian species

AU - Denison, Michael S.

AU - Wilkinson, Christopher F.

AU - Okey, Allan B.

PY - 1986

Y1 - 1986

N2 - The Ah receptor was identified and characterized in cytosol from a large number of diverse animal species. Molecular properties of the Ah receptor were similar in all species which had detectable receptor. However, subtle differences in receptor properties exist among animal species and these differences indicate that the Ah receptor protein is not identical in all species. It is not yet known whether differences in receptor properties among animal species play a significant role in determining differential susceptibility of the species to toxicity from halogenated aromatic compounds.

AB - The Ah receptor was identified and characterized in cytosol from a large number of diverse animal species. Molecular properties of the Ah receptor were similar in all species which had detectable receptor. However, subtle differences in receptor properties exist among animal species and these differences indicate that the Ah receptor protein is not identical in all species. It is not yet known whether differences in receptor properties among animal species play a significant role in determining differential susceptibility of the species to toxicity from halogenated aromatic compounds.

UR - http://www.scopus.com/inward/record.url?scp=0022907676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022907676&partnerID=8YFLogxK

U2 - 10.1016/0045-6535(86)90452-2

DO - 10.1016/0045-6535(86)90452-2

M3 - Article

VL - 15

SP - 1665

EP - 1672

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 9-12

ER -