Ah receptor and NF-κB interactions, a potential mechanism for dioxin toxicity

Yanan Tian, Sui Ke, Michael S. Denison, Arnold B. Rabson, Michael A. Gallo

Research output: Contribution to journalArticlepeer-review

298 Scopus citations

Abstract

The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife. NF- κB is a pleiotropic transcription factor controlling many physiological functions adversely affected by PAHs, including immune suppression, thymus involution, hyperkeratosis, and carcinogenesis. Here, we show physical interaction and mutual functional repression between AhR and NF-κB. This mutual repression may provide an underlying mechanism for many hitherto poorly understood PAH-induced toxic responses, and may also provide a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and compounds that regulate NF-κB.

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalJournal of Biological Chemistry
Volume274
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Biochemistry

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