Agglutinins to bacteria in Crohn's disease

N. Matthews, J. F. Mayberry, J. Rhodes, L. Neale, J. Munro, F. Wensinck, G. H. Lawson, A. C. Rowland, G. A. Berkhoff, Stephen W Barthold

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Sera from patients with Crohn's disease were tested for antibodies against organisms which are thought to cause inflammatory bowel disease in animals, or have been implicated in human Crohn's disease. Control sera were collected from healthy individuals and patients with ulcerative colitis. Sera from Crohn's disease and controls failed to agglutinate Clostridium colinum or Campylobacter sputorum subsp. mucosalis and two strains of Mycobacterium paratuberculosis (M26 and M27). Most of the sera agglutinated a Citrobacter freundii variant, Mycobacterium paratuberculosis (M28) and Mycobacterium avium (M41) but Crohn's disease sera did not differ from controls. A complement fixation test against Chlamydia gave more positive reactions in patients with Crohn's disease and colitis than in healthy controls. There was a clear difference between the sera from patients with Crohn's disease and other sera, including ulcerative colitis, in agglutination test with the commensal coccoid rods of the genera Eubacterium and Peptostreptococcus; in these tests 54% of sera from Crohn's disease were positive compared with 11% in ulcerative colitis and none of the sera from healthy controls. All the results were essentially negative with the exception of those from Eubacterium and Peptostreptococcus and these bacteria merit investigation.

Original languageEnglish (US)
Pages (from-to)376-380
Number of pages5
JournalGut
Volume21
Issue number5
StatePublished - 1980
Externally publishedYes

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Agglutinins
Crohn Disease
Bacteria
Serum
Ulcerative Colitis
Mycobacterium avium subsp. paratuberculosis
Eubacterium
Peptostreptococcus
Campylobacter sputorum
Citrobacter freundii
Complement Fixation Tests
Mycobacterium avium
Agglutination Tests
Clostridium
Chlamydia
Colitis
Inflammatory Bowel Diseases
Antibodies

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Matthews, N., Mayberry, J. F., Rhodes, J., Neale, L., Munro, J., Wensinck, F., ... Barthold, S. W. (1980). Agglutinins to bacteria in Crohn's disease. Gut, 21(5), 376-380.

Agglutinins to bacteria in Crohn's disease. / Matthews, N.; Mayberry, J. F.; Rhodes, J.; Neale, L.; Munro, J.; Wensinck, F.; Lawson, G. H.; Rowland, A. C.; Berkhoff, G. A.; Barthold, Stephen W.

In: Gut, Vol. 21, No. 5, 1980, p. 376-380.

Research output: Contribution to journalArticle

Matthews, N, Mayberry, JF, Rhodes, J, Neale, L, Munro, J, Wensinck, F, Lawson, GH, Rowland, AC, Berkhoff, GA & Barthold, SW 1980, 'Agglutinins to bacteria in Crohn's disease', Gut, vol. 21, no. 5, pp. 376-380.
Matthews N, Mayberry JF, Rhodes J, Neale L, Munro J, Wensinck F et al. Agglutinins to bacteria in Crohn's disease. Gut. 1980;21(5):376-380.
Matthews, N. ; Mayberry, J. F. ; Rhodes, J. ; Neale, L. ; Munro, J. ; Wensinck, F. ; Lawson, G. H. ; Rowland, A. C. ; Berkhoff, G. A. ; Barthold, Stephen W. / Agglutinins to bacteria in Crohn's disease. In: Gut. 1980 ; Vol. 21, No. 5. pp. 376-380.
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