Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque

Gene E. Alexander, Kewei Chen, Melaney Aschenbrenner, Tricia L. Merkley, Laura E. Santerre-Lemmon, Jul Lea Shamy, William E. Skaggs, Michael H. Buonocore, Peter R. Rapp, Carol A. Barnes

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Humanstructural neuroimaging studies have supported the preferential effects of healthy aging on frontal cortex, but reductions in other brain regions have also been observed. We investigated the regional network pattern of gray matter using magnetic resonance imaging (MRI) in young adult and old rhesus macaques (RMs) to evaluate age effects throughout the brain in a nonhuman primate model of healthy aging in which the full complement of Alzheimer's disease (AD) pathology does not occur. Volumetric T1 MRI scans were spatially normalized and segmented for gray matter using statistical parametric mapping (SPM2) voxel-based morphometry. Multivariate network analysis using the scaled subprofile model identified a linear combination of two gray matter patterns that distinguished the young from old RMs. The combined pattern included reductions in bilateral dorsolateral and ventrolateral prefrontal and orbitofrontal and superior temporal sulcal regions with areas of relative preservation in vicinities of the cerebellum, globus pallidus, visual cortex, and parietal cortex in old compared with young RMs. Higher expression of this age-related gray matter pattern was associated with poorer performance in working memory. In the RM model of healthy aging, the major regionally distributed effects of advanced age on the brain involve reductions in prefrontal regions and in the vicinity of the superior temporal sulcus. The age-related differences in gray matter reflect the effects of healthy aging that cannot be attributed to AD pathology, providing support for the targeted effects of aging on the integrity of frontal lobe regions and selective temporal lobe areas and their associated cognitive functions.

Original languageEnglish (US)
Pages (from-to)2710-2718
Number of pages9
JournalJournal of Neuroscience
Volume28
Issue number11
DOIs
StatePublished - Mar 12 2008

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Macaca mulatta
Magnetic Resonance Imaging
Temporal Lobe
Frontal Lobe
Alzheimer Disease
Brain
Pathology
Parietal Lobe
Globus Pallidus
Visual Cortex
Short-Term Memory
Neuroimaging
Cerebellum
Cognition
Primates
Young Adult
Multivariate Analysis
Gray Matter

Keywords

  • Aging
  • Behavior
  • Monkey
  • Multivariate analysis
  • Prefrontal cortex
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alexander, G. E., Chen, K., Aschenbrenner, M., Merkley, T. L., Santerre-Lemmon, L. E., Shamy, J. L., ... Barnes, C. A. (2008). Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque. Journal of Neuroscience, 28(11), 2710-2718. https://doi.org/10.1523/JNEUROSCI.1852-07.2008

Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque. / Alexander, Gene E.; Chen, Kewei; Aschenbrenner, Melaney; Merkley, Tricia L.; Santerre-Lemmon, Laura E.; Shamy, Jul Lea; Skaggs, William E.; Buonocore, Michael H.; Rapp, Peter R.; Barnes, Carol A.

In: Journal of Neuroscience, Vol. 28, No. 11, 12.03.2008, p. 2710-2718.

Research output: Contribution to journalArticle

Alexander, GE, Chen, K, Aschenbrenner, M, Merkley, TL, Santerre-Lemmon, LE, Shamy, JL, Skaggs, WE, Buonocore, MH, Rapp, PR & Barnes, CA 2008, 'Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque', Journal of Neuroscience, vol. 28, no. 11, pp. 2710-2718. https://doi.org/10.1523/JNEUROSCI.1852-07.2008
Alexander GE, Chen K, Aschenbrenner M, Merkley TL, Santerre-Lemmon LE, Shamy JL et al. Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque. Journal of Neuroscience. 2008 Mar 12;28(11):2710-2718. https://doi.org/10.1523/JNEUROSCI.1852-07.2008
Alexander, Gene E. ; Chen, Kewei ; Aschenbrenner, Melaney ; Merkley, Tricia L. ; Santerre-Lemmon, Laura E. ; Shamy, Jul Lea ; Skaggs, William E. ; Buonocore, Michael H. ; Rapp, Peter R. ; Barnes, Carol A. / Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 11. pp. 2710-2718.
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