Abstract
Purpose of review: Significant changes in population demographics with respect to age have taken place, and this pattern is expected to continue. The aging of the population underscores the importance of finding ways to improve the quality of life of the elderly. Most of the elderly population, however, suffers from progressive hearing loss: 60% of people older than 70 years have hearing loss of at least 25 dB. Age-related hearing loss affects the quality of life, not only of the elderly but also of their families and loved ones. Recent findings: The research goal in this field is to elucidate the mechanisms involved in age-related hearing loss and the molecular basis of normal and impaired auditory function, with the aim of developing preventative therapies. During the past few years, extraordinary progress has been made in the identification of genes that contribute to deafness. Additionally, inbred strains of mice have proven to be useful models to identify specific factors relevant to age-related hearing loss. A detailed description of the pathology exhibited by inbred mice that exhibit age-related hearing loss is helping to identify the specific structures and cell types affected by age-related hearing loss. A summary of current research efforts is presented. This review focuses on studies using inbred mice. Summary: By defining the molecular basis of normal and impaired auditory function, therapies can be developed to ameliorate the effects of aging in the auditory system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 367-371 |
| Number of pages | 5 |
| Journal | Current Opinion in Otolaryngology and Head and Neck Surgery |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 2003 |
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Keywords
- Age-related hearing loss
- Ahl
- Cadherin 23
- Cochlea
- Otocadherin
- Presbycusis
ASJC Scopus subject areas
- Otorhinolaryngology
- Surgery
Cite this
Age-related hearing loss : Current research. / Gratton, Michael Anne; Vázquez, Ana Elena.
In: Current Opinion in Otolaryngology and Head and Neck Surgery, Vol. 11, No. 5, 10.2003, p. 367-371.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related hearing loss
T2 - Current research
AU - Gratton, Michael Anne
AU - Vázquez, Ana Elena
PY - 2003/10
Y1 - 2003/10
N2 - Purpose of review: Significant changes in population demographics with respect to age have taken place, and this pattern is expected to continue. The aging of the population underscores the importance of finding ways to improve the quality of life of the elderly. Most of the elderly population, however, suffers from progressive hearing loss: 60% of people older than 70 years have hearing loss of at least 25 dB. Age-related hearing loss affects the quality of life, not only of the elderly but also of their families and loved ones. Recent findings: The research goal in this field is to elucidate the mechanisms involved in age-related hearing loss and the molecular basis of normal and impaired auditory function, with the aim of developing preventative therapies. During the past few years, extraordinary progress has been made in the identification of genes that contribute to deafness. Additionally, inbred strains of mice have proven to be useful models to identify specific factors relevant to age-related hearing loss. A detailed description of the pathology exhibited by inbred mice that exhibit age-related hearing loss is helping to identify the specific structures and cell types affected by age-related hearing loss. A summary of current research efforts is presented. This review focuses on studies using inbred mice. Summary: By defining the molecular basis of normal and impaired auditory function, therapies can be developed to ameliorate the effects of aging in the auditory system.
AB - Purpose of review: Significant changes in population demographics with respect to age have taken place, and this pattern is expected to continue. The aging of the population underscores the importance of finding ways to improve the quality of life of the elderly. Most of the elderly population, however, suffers from progressive hearing loss: 60% of people older than 70 years have hearing loss of at least 25 dB. Age-related hearing loss affects the quality of life, not only of the elderly but also of their families and loved ones. Recent findings: The research goal in this field is to elucidate the mechanisms involved in age-related hearing loss and the molecular basis of normal and impaired auditory function, with the aim of developing preventative therapies. During the past few years, extraordinary progress has been made in the identification of genes that contribute to deafness. Additionally, inbred strains of mice have proven to be useful models to identify specific factors relevant to age-related hearing loss. A detailed description of the pathology exhibited by inbred mice that exhibit age-related hearing loss is helping to identify the specific structures and cell types affected by age-related hearing loss. A summary of current research efforts is presented. This review focuses on studies using inbred mice. Summary: By defining the molecular basis of normal and impaired auditory function, therapies can be developed to ameliorate the effects of aging in the auditory system.
KW - Age-related hearing loss
KW - Ahl
KW - Cadherin 23
KW - Cochlea
KW - Otocadherin
KW - Presbycusis
UR - http://www.scopus.com/inward/record.url?scp=0141729425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141729425&partnerID=8YFLogxK
U2 - 10.1097/00020840-200310000-00010
DO - 10.1097/00020840-200310000-00010
M3 - Article
C2 - 14502068
AN - SCOPUS:0141729425
VL - 11
SP - 367
EP - 371
JO - Current Opinion in Otolaryngology and Head and Neck Surgery
JF - Current Opinion in Otolaryngology and Head and Neck Surgery
SN - 1068-9508
IS - 5
ER -