Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats

Robert F Berman, H. Goldman, H. J. Altman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Studies of regional cerebral blood flow (rCBF) were carried out in male, Sprague-Dawley rats at ages 6, 12 and 24 months. These animals were characterized behaviorally for their ability to learn a complex 14-choice sequential T-maze (i.e., Stone maze) for food reward. Old animals (i.e., 24 month) demonstrated a clear and consistent impairment in maze performance which correlated significantly with decreased cortical blood flow. The results are discussed in relation to cerebral blood flow studies in aging humans and as they relate to the use of rats, the Sprague-Dawley strain in particular, to study brain aging.

Original languageEnglish (US)
Pages (from-to)691-696
Number of pages6
JournalNeurobiology of Aging
Volume9
Issue numberC
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Sprague Dawley Rats
Aptitude
Reward
Food
Brain

Keywords

  • Acetylcholine
  • Maze learning
  • Models of aging
  • Regional cerebral blood flow
  • Sprague-Dawley rats
  • Stone maze

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neuroscience(all)
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats. / Berman, Robert F; Goldman, H.; Altman, H. J.

In: Neurobiology of Aging, Vol. 9, No. C, 1988, p. 691-696.

Research output: Contribution to journalArticle

@article{2a465fa74a2a4749a23c7378aa8553cb,
title = "Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats",
abstract = "Studies of regional cerebral blood flow (rCBF) were carried out in male, Sprague-Dawley rats at ages 6, 12 and 24 months. These animals were characterized behaviorally for their ability to learn a complex 14-choice sequential T-maze (i.e., Stone maze) for food reward. Old animals (i.e., 24 month) demonstrated a clear and consistent impairment in maze performance which correlated significantly with decreased cortical blood flow. The results are discussed in relation to cerebral blood flow studies in aging humans and as they relate to the use of rats, the Sprague-Dawley strain in particular, to study brain aging.",
keywords = "Acetylcholine, Maze learning, Models of aging, Regional cerebral blood flow, Sprague-Dawley rats, Stone maze",
author = "Berman, {Robert F} and H. Goldman and Altman, {H. J.}",
year = "1988",
doi = "10.1016/S0197-4580(88)80134-9",
language = "English (US)",
volume = "9",
pages = "691--696",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "C",

}

TY - JOUR

T1 - Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats

AU - Berman, Robert F

AU - Goldman, H.

AU - Altman, H. J.

PY - 1988

Y1 - 1988

N2 - Studies of regional cerebral blood flow (rCBF) were carried out in male, Sprague-Dawley rats at ages 6, 12 and 24 months. These animals were characterized behaviorally for their ability to learn a complex 14-choice sequential T-maze (i.e., Stone maze) for food reward. Old animals (i.e., 24 month) demonstrated a clear and consistent impairment in maze performance which correlated significantly with decreased cortical blood flow. The results are discussed in relation to cerebral blood flow studies in aging humans and as they relate to the use of rats, the Sprague-Dawley strain in particular, to study brain aging.

AB - Studies of regional cerebral blood flow (rCBF) were carried out in male, Sprague-Dawley rats at ages 6, 12 and 24 months. These animals were characterized behaviorally for their ability to learn a complex 14-choice sequential T-maze (i.e., Stone maze) for food reward. Old animals (i.e., 24 month) demonstrated a clear and consistent impairment in maze performance which correlated significantly with decreased cortical blood flow. The results are discussed in relation to cerebral blood flow studies in aging humans and as they relate to the use of rats, the Sprague-Dawley strain in particular, to study brain aging.

KW - Acetylcholine

KW - Maze learning

KW - Models of aging

KW - Regional cerebral blood flow

KW - Sprague-Dawley rats

KW - Stone maze

UR - http://www.scopus.com/inward/record.url?scp=0024156737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024156737&partnerID=8YFLogxK

U2 - 10.1016/S0197-4580(88)80134-9

DO - 10.1016/S0197-4580(88)80134-9

M3 - Article

VL - 9

SP - 691

EP - 696

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - C

ER -