Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats

Robert F Berman, H. Goldman, H. J. Altman

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Studies of regional cerebral blood flow (rCBF) were carried out in male, Sprague-Dawley rats at ages 6, 12 and 24 months. These animals were characterized behaviorally for their ability to learn a complex 14-choice sequential T-maze (i.e., Stone maze) for food reward. Old animals (i.e., 24 month) demonstrated a clear and consistent impairment in maze performance which correlated significantly with decreased cortical blood flow. The results are discussed in relation to cerebral blood flow studies in aging humans and as they relate to the use of rats, the Sprague-Dawley strain in particular, to study brain aging.

Original languageEnglish (US)
Pages (from-to)691-696
Number of pages6
JournalNeurobiology of Aging
Volume9
Issue numberC
DOIs
StatePublished - 1988
Externally publishedYes

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Keywords

  • Acetylcholine
  • Maze learning
  • Models of aging
  • Regional cerebral blood flow
  • Sprague-Dawley rats
  • Stone maze

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neuroscience(all)
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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