Abstract
Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-88 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 297 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 12 2001 |
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Keywords
- Aging
- CA1 Pyramidal cells
- Hippocampus
- Long-term potentiation
- Mesocricetus auratus
- Neural plasticity
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus. / Shahlaie, Kiarash; Kargozaran, Hamed; Horowitz, John M.
In: Neuroscience Letters, Vol. 297, No. 2, 12.01.2001, p. 85-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus
AU - Shahlaie, Kiarash
AU - Kargozaran, Hamed
AU - Horowitz, John M.
PY - 2001/1/12
Y1 - 2001/1/12
N2 - Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.
AB - Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.
KW - Aging
KW - CA1 Pyramidal cells
KW - Hippocampus
KW - Long-term potentiation
KW - Mesocricetus auratus
KW - Neural plasticity
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UR - http://www.scopus.com/inward/citedby.url?scp=0035846833&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(00)01680-3
DO - 10.1016/S0304-3940(00)01680-3
M3 - Article
C2 - 11121876
AN - SCOPUS:0035846833
VL - 297
SP - 85
EP - 88
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -