Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus

Kiarash Shahlaie; Hamed Kargozaran; John M. Horowitz

doi:10.1016/S0304-3940(00)01680-3

Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus

Kiarash Shahlaie, Hamed Kargozaran, John M. Horowitz

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	85-88
Number of pages	4
Journal	Neuroscience Letters
Volume	297
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(00)01680-3
State	Published - Jan 12 2001

Keywords

Aging
CA1 Pyramidal cells
Hippocampus
Long-term potentiation
Mesocricetus auratus
Neural plasticity

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(00)01680-3

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title = "Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus",

abstract = "Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.",

keywords = "Aging, CA1 Pyramidal cells, Hippocampus, Long-term potentiation, Mesocricetus auratus, Neural plasticity",

author = "Kiarash Shahlaie and Hamed Kargozaran and Horowitz, {John M.}",

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AU - Kargozaran, Hamed

AU - Horowitz, John M.

PY - 2001/1/12

Y1 - 2001/1/12

N2 - Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.

AB - Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.

KW - Aging

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KW - Hippocampus

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KW - Neural plasticity

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