Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus

Kiarash Shahlaie, Hamed Kargozaran, John M. Horowitz

Research output: Contribution to journalArticle

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Abstract

Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalNeuroscience Letters
Volume297
Issue number2
DOIs
StatePublished - Jan 12 2001

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Pyramidal Cells
Cricetinae
Hippocampus
Tetanus
Mesocricetus
Population

Keywords

  • Aging
  • CA1 Pyramidal cells
  • Hippocampus
  • Long-term potentiation
  • Mesocricetus auratus
  • Neural plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Age-related changes in potentiation of evoked responses in CA1 pyramidal cells from the hamster hippocampus. / Shahlaie, Kiarash; Kargozaran, Hamed; Horowitz, John M.

In: Neuroscience Letters, Vol. 297, No. 2, 12.01.2001, p. 85-88.

Research output: Contribution to journalArticle

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AB - Hippocampal responses were compared in 16 old (15-22 month) and 14 young (2-5 month) Syrian hamsters to determine if this species showed age-dependent changes in potentiation. Population spike amplitude increased following tetanus by 84.1 ± 20.0% in slices from young animals and by 51.1 ± 6.3% in slices from old animals (P < 0.05). In addition, I-O curves (plots of population spike amplitude vs. intensity of Schaffer collateral excitation) were obtained before and after tetanus. While regions of I-O curves near threshold and saturation showed no significant change, the slope at the midpoint of the I-O curve increased by 152.3 ± 68.4% in slices from young animals and by 13.7 ± 10.0% in slices from old animals (P < 0.05). Thus, in old hamsters (as in rats) potentiation was impaired and slope changes of I/O curves clearly displayed this deficit. (C) 2001 Elsevier Science Ireland Ltd.

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