Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice

Zhe Xiong Lian, Tomoyuki Okada, Hiroto Kita, Hsu Tom, Leonard D. Shultz, Kenneth Dorshkind, Aftab A. Ansari, Mitsuru Naiki, Susumu Ikehara, M. Eric Gershwin

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2 Scopus citations

Abstract

Significant disturbances in B lineage populations of New Zealand Black (NZB) mice have been reported, both with respect to their phenotypes as well as to their function. Notably, there is a profound age-dependent decrease in B-cell precursors in this strain of lupus prone mice. In efforts to characterize the impact of this disturbance in disease, we performed an intensive phenotypic and B-cell population analysis in young and old NZB mice. Our results revealed that there was a significant age-dependent decrease in B cell precursors at all levels of the B-cell-lineage developmental pathway. Analysis of the proliferative capacity of these cell populations showed a comparative decrease in cycling activity in the B-cell-lineage populations of old NZB mice. Furthermore, these cell subsets were much more susceptible to spontaneous apoptosis when compared with similar populations from age-matched BALB/c or young NZB mice. Since the frequency of cells that express the interleukin-7 receptor (IL-7R) declines as NZB mice age, we hypothesize that impairment of IL-7R signal transduction pathways could contribute to severe perturbations of B-cell function in aged NZB mice.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalStem Cells
Volume20
Issue number4
StatePublished - 2002

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Keywords

  • Aging B cells
  • Autoimmunity
  • B lymphocytes
  • IL-7R
  • NZB mice
  • Pro-B cells

ASJC Scopus subject areas

  • Cell Biology

Cite this

Lian, Z. X., Okada, T., Kita, H., Tom, H., Shultz, L. D., Dorshkind, K., Ansari, A. A., Naiki, M., Ikehara, S., & Gershwin, M. E. (2002). Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. Stem Cells, 20(4), 293-300.