Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice

Zhe Xiong Lian, Tomoyuki Okada, Hiroto Kita, Hsu Tom, Leonard D. Shultz, Kenneth Dorshkind, Aftab A. Ansari, Mitsuru Naiki, Susumu Ikehara, M. Eric Gershwin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Significant disturbances in B lineage populations of New Zealand Black (NZB) mice have been reported, both with respect to their phenotypes as well as to their function. Notably, there is a profound age-dependent decrease in B-cell precursors in this strain of lupus prone mice. In efforts to characterize the impact of this disturbance in disease, we performed an intensive phenotypic and B-cell population analysis in young and old NZB mice. Our results revealed that there was a significant age-dependent decrease in B cell precursors at all levels of the B-cell-lineage developmental pathway. Analysis of the proliferative capacity of these cell populations showed a comparative decrease in cycling activity in the B-cell-lineage populations of old NZB mice. Furthermore, these cell subsets were much more susceptible to spontaneous apoptosis when compared with similar populations from age-matched BALB/c or young NZB mice. Since the frequency of cells that express the interleukin-7 receptor (IL-7R) declines as NZB mice age, we hypothesize that impairment of IL-7R signal transduction pathways could contribute to severe perturbations of B-cell function in aged NZB mice.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalStem Cells
Volume20
Issue number4
StatePublished - 2002

Fingerprint

New Zealand
Population
B-Lymphocytes
Interleukin-7 Receptors
B-Lymphoid Precursor Cells
Cell Lineage
Signal Transduction
Apoptosis
Phenotype

Keywords

  • Aging B cells
  • Autoimmunity
  • B lymphocytes
  • IL-7R
  • NZB mice
  • Pro-B cells

ASJC Scopus subject areas

  • Cell Biology

Cite this

Lian, Z. X., Okada, T., Kita, H., Tom, H., Shultz, L. D., Dorshkind, K., ... Gershwin, M. E. (2002). Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. Stem Cells, 20(4), 293-300.

Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. / Lian, Zhe Xiong; Okada, Tomoyuki; Kita, Hiroto; Tom, Hsu; Shultz, Leonard D.; Dorshkind, Kenneth; Ansari, Aftab A.; Naiki, Mitsuru; Ikehara, Susumu; Gershwin, M. Eric.

In: Stem Cells, Vol. 20, No. 4, 2002, p. 293-300.

Research output: Contribution to journalArticle

Lian, ZX, Okada, T, Kita, H, Tom, H, Shultz, LD, Dorshkind, K, Ansari, AA, Naiki, M, Ikehara, S & Gershwin, ME 2002, 'Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice', Stem Cells, vol. 20, no. 4, pp. 293-300.
Lian ZX, Okada T, Kita H, Tom H, Shultz LD, Dorshkind K et al. Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. Stem Cells. 2002;20(4):293-300.
Lian, Zhe Xiong ; Okada, Tomoyuki ; Kita, Hiroto ; Tom, Hsu ; Shultz, Leonard D. ; Dorshkind, Kenneth ; Ansari, Aftab A. ; Naiki, Mitsuru ; Ikehara, Susumu ; Gershwin, M. Eric. / Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. In: Stem Cells. 2002 ; Vol. 20, No. 4. pp. 293-300.
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