Age effects on atrophy rates of entorhinal cortex and hippocampus

An Tao Du, Norbert Schuff, Linda L. Chao, John Kornak, William J. Jagust, Joel H. Kramer, Bruce R Reed, Bruce L. Miller, David Norman, Helena C. Chui, Michael W. Weiner

Research output: Contribution to journalArticlepeer-review

162 Scopus citations


The effects of age, subcortical vascular disease, apolipoprotein E (APOE) ε4 allele and hypertension on entorhinal cortex (ERC) and hippocampal atrophy rates were explored in a longitudinal MRI study with 42 cognitively normal (CN) elderly subjects from 58 to 87 years old. The volumes of the ERC, hippocampus, and white matter hyperintensities (WMH) and the presence of lacunes were assessed on MR images. Age was significantly associated with increased atrophy rates of 0.04 ± 0.02% per year for ERC and 0.05 ± 0.02% per year for hippocampus. Atrophy rates of hippocampus, but not that of ERC increased with presence of lacunes, in addition to age. WMH, APOE ε4 and hypertension had no significant effect on atrophy rates. In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials.

Original languageEnglish (US)
Pages (from-to)733-740
Number of pages8
JournalNeurobiology of Aging
Issue number5
StatePublished - May 2006


  • APOE ε4
  • Atrophy rate
  • Hypertension
  • Normal aging
  • Subcortical vascular disease
  • The entorhinal cortex
  • The hippocampus

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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