Age-dependent decline in extracellular matrix-induced local bone differentiation

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Implantation of demineralized bone matrix in subcutaneous sites in the rat results in new bone induction. This model system was examined with bone matrix prepared from young (4-month-old) and old (24-month-old) rats. The implants were removed on Days 9, 14 and 21 and examined for alkaline phosphatase activity and 45Ca incorporation. There is a significant decline in the osteo-inductive potential of the bone matrix derived from 24-month-old rats, as quantitated by the enzyme activity and 45Ca incorporation.

Original languageEnglish (US)
Pages (from-to)312-313
Number of pages2
JournalIsrael Journal of Medical Sciences
Volume21
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Bone Matrix
Extracellular Matrix
Bone
Rats
Bone and Bones
Alkaline Phosphatase
Phosphatases
Enzyme activity
Enzymes

ASJC Scopus subject areas

  • Bioengineering
  • Medicine(all)

Cite this

Age-dependent decline in extracellular matrix-induced local bone differentiation. / Reddi, A Hari.

In: Israel Journal of Medical Sciences, Vol. 21, No. 3, 1985, p. 312-313.

Research output: Contribution to journalArticle

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