Implantation of demineralized bone matrix in subcutaneous sites in the rat results in new bone induction. This model system was examined with bone matrix prepared from young (4-month-old) and old (24-month-old) rats. The implants were removed on Days 9, 14 and 21 and examined for alkaline phosphatase activity and 45Ca incorporation. There is a significant decline in the osteo-inductive potential of the bone matrix derived from 24-month-old rats, as quantitated by the enzyme activity and 45Ca incorporation.
|Original language||English (US)|
|Number of pages||2|
|Journal||Israel Journal of Medical Sciences|
|State||Published - 1985|
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