Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome

Kang Hoon Lee, Sophia Chiu, Young Kwan Lee, David G Greenhalgh, Kiho Cho

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5. weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalExperimental and Molecular Pathology
Volume93
Issue number1
DOIs
StatePublished - Aug 2012

Fingerprint

Retroelements
Inbred C57BL Mouse
Genes
Genome
Tissue
Liver
Biological Phenomena
Genome Size
Phenotype

Keywords

  • Age
  • Genome size
  • Genome structure
  • Retroelement
  • Tissue

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome. / Lee, Kang Hoon; Chiu, Sophia; Lee, Young Kwan; Greenhalgh, David G; Cho, Kiho.

In: Experimental and Molecular Pathology, Vol. 93, No. 1, 08.2012, p. 167-172.

Research output: Contribution to journalArticle

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