Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows

Gayle C. Windham, Raymond Lum, Robert Voss, Mary Wolff, Susan M. Pinney, Susan L. Teteilbaum, Connie S. Sosnoff, Dina Dobraca, Frank Biro, Robert A. Hiatt, Louise C. Greenspan, Maida Galvez, Lawrence H. Kushi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND:: Tobacco smoke contains known hormonally active chemicals and reproductive toxicants. Several studies have examined prenatal maternal smoking and offspring age at menarche, but few examined earlier pubertal markers, nor accounted for exposure during childhood. Our objective was to examine pre- and post-natal smoke exposure in relation to timing of early pubertal events. METHODS:: An ethnically diverse cohort of 1239 girls was enrolled at age 6-8 years for a longitudinal study of puberty at three U.S. sites. Girls participated in annual or semi-annual exams to measure anthropometry and Tanner breast and pubic hair stages. Prenatal and current tobacco smoke exposures, as well as covariates, were obtained from parent questionnaire. Cotinine was measured in urine collected at enrollment. Using accelerated failure time models, we calculated adjusted time ratios for age at pubertal onset (maturation stages 2 or higher) and smoke exposure. RESULTS:: Girls with higher prenatal (≥5 cigarettes/day) or secondhand smoke exposure had earlier pubic hair development than unexposed (adjusted time ratio = 0.92 (95% CI 0.87-0.97) and 0.94 (95% CI 0.90-0.97), respectively). Including both exposures in the same model yielded similar associations. Higher urinary cotinine quartiles were associated with younger age at breast and pubic hair onset in unadjusted models, but not after adjustment. CONCLUSIONS:: Greater prenatal and childhood secondhand smoke exposure were associated with earlier onset of pubic hair, but not breast, development. These exposures represent modifiable risk factors for early pubertal development that should be considered for addition to the extensive list of adverse effects from tobacco smoke.

Original languageEnglish (US)
JournalEpidemiology
DOIs
StateAccepted/In press - Jun 28 2017

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Age of Onset
Smoke
Tobacco
Hair
Cotinine
Tobacco Smoke Pollution
Breast
Social Adjustment
Anthropometry
Menarche
Puberty
Tobacco Products
Longitudinal Studies
Smoking
Mothers
Urine

ASJC Scopus subject areas

  • Epidemiology

Cite this

Windham, G. C., Lum, R., Voss, R., Wolff, M., Pinney, S. M., Teteilbaum, S. L., ... Kushi, L. H. (Accepted/In press). Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows. Epidemiology. https://doi.org/10.1097/EDE.0000000000000704

Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows. / Windham, Gayle C.; Lum, Raymond; Voss, Robert; Wolff, Mary; Pinney, Susan M.; Teteilbaum, Susan L.; Sosnoff, Connie S.; Dobraca, Dina; Biro, Frank; Hiatt, Robert A.; Greenspan, Louise C.; Galvez, Maida; Kushi, Lawrence H.

In: Epidemiology, 28.06.2017.

Research output: Contribution to journalArticle

Windham, GC, Lum, R, Voss, R, Wolff, M, Pinney, SM, Teteilbaum, SL, Sosnoff, CS, Dobraca, D, Biro, F, Hiatt, RA, Greenspan, LC, Galvez, M & Kushi, LH 2017, 'Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows', Epidemiology. https://doi.org/10.1097/EDE.0000000000000704
Windham, Gayle C. ; Lum, Raymond ; Voss, Robert ; Wolff, Mary ; Pinney, Susan M. ; Teteilbaum, Susan L. ; Sosnoff, Connie S. ; Dobraca, Dina ; Biro, Frank ; Hiatt, Robert A. ; Greenspan, Louise C. ; Galvez, Maida ; Kushi, Lawrence H. / Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows. In: Epidemiology. 2017.
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abstract = "BACKGROUND:: Tobacco smoke contains known hormonally active chemicals and reproductive toxicants. Several studies have examined prenatal maternal smoking and offspring age at menarche, but few examined earlier pubertal markers, nor accounted for exposure during childhood. Our objective was to examine pre- and post-natal smoke exposure in relation to timing of early pubertal events. METHODS:: An ethnically diverse cohort of 1239 girls was enrolled at age 6-8 years for a longitudinal study of puberty at three U.S. sites. Girls participated in annual or semi-annual exams to measure anthropometry and Tanner breast and pubic hair stages. Prenatal and current tobacco smoke exposures, as well as covariates, were obtained from parent questionnaire. Cotinine was measured in urine collected at enrollment. Using accelerated failure time models, we calculated adjusted time ratios for age at pubertal onset (maturation stages 2 or higher) and smoke exposure. RESULTS:: Girls with higher prenatal (≥5 cigarettes/day) or secondhand smoke exposure had earlier pubic hair development than unexposed (adjusted time ratio = 0.92 (95{\%} CI 0.87-0.97) and 0.94 (95{\%} CI 0.90-0.97), respectively). Including both exposures in the same model yielded similar associations. Higher urinary cotinine quartiles were associated with younger age at breast and pubic hair onset in unadjusted models, but not after adjustment. CONCLUSIONS:: Greater prenatal and childhood secondhand smoke exposure were associated with earlier onset of pubic hair, but not breast, development. These exposures represent modifiable risk factors for early pubertal development that should be considered for addition to the extensive list of adverse effects from tobacco smoke.",
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AU - Windham, Gayle C.

AU - Lum, Raymond

AU - Voss, Robert

AU - Wolff, Mary

AU - Pinney, Susan M.

AU - Teteilbaum, Susan L.

AU - Sosnoff, Connie S.

AU - Dobraca, Dina

AU - Biro, Frank

AU - Hiatt, Robert A.

AU - Greenspan, Louise C.

AU - Galvez, Maida

AU - Kushi, Lawrence H.

PY - 2017/6/28

Y1 - 2017/6/28

N2 - BACKGROUND:: Tobacco smoke contains known hormonally active chemicals and reproductive toxicants. Several studies have examined prenatal maternal smoking and offspring age at menarche, but few examined earlier pubertal markers, nor accounted for exposure during childhood. Our objective was to examine pre- and post-natal smoke exposure in relation to timing of early pubertal events. METHODS:: An ethnically diverse cohort of 1239 girls was enrolled at age 6-8 years for a longitudinal study of puberty at three U.S. sites. Girls participated in annual or semi-annual exams to measure anthropometry and Tanner breast and pubic hair stages. Prenatal and current tobacco smoke exposures, as well as covariates, were obtained from parent questionnaire. Cotinine was measured in urine collected at enrollment. Using accelerated failure time models, we calculated adjusted time ratios for age at pubertal onset (maturation stages 2 or higher) and smoke exposure. RESULTS:: Girls with higher prenatal (≥5 cigarettes/day) or secondhand smoke exposure had earlier pubic hair development than unexposed (adjusted time ratio = 0.92 (95% CI 0.87-0.97) and 0.94 (95% CI 0.90-0.97), respectively). Including both exposures in the same model yielded similar associations. Higher urinary cotinine quartiles were associated with younger age at breast and pubic hair onset in unadjusted models, but not after adjustment. CONCLUSIONS:: Greater prenatal and childhood secondhand smoke exposure were associated with earlier onset of pubic hair, but not breast, development. These exposures represent modifiable risk factors for early pubertal development that should be considered for addition to the extensive list of adverse effects from tobacco smoke.

AB - BACKGROUND:: Tobacco smoke contains known hormonally active chemicals and reproductive toxicants. Several studies have examined prenatal maternal smoking and offspring age at menarche, but few examined earlier pubertal markers, nor accounted for exposure during childhood. Our objective was to examine pre- and post-natal smoke exposure in relation to timing of early pubertal events. METHODS:: An ethnically diverse cohort of 1239 girls was enrolled at age 6-8 years for a longitudinal study of puberty at three U.S. sites. Girls participated in annual or semi-annual exams to measure anthropometry and Tanner breast and pubic hair stages. Prenatal and current tobacco smoke exposures, as well as covariates, were obtained from parent questionnaire. Cotinine was measured in urine collected at enrollment. Using accelerated failure time models, we calculated adjusted time ratios for age at pubertal onset (maturation stages 2 or higher) and smoke exposure. RESULTS:: Girls with higher prenatal (≥5 cigarettes/day) or secondhand smoke exposure had earlier pubic hair development than unexposed (adjusted time ratio = 0.92 (95% CI 0.87-0.97) and 0.94 (95% CI 0.90-0.97), respectively). Including both exposures in the same model yielded similar associations. Higher urinary cotinine quartiles were associated with younger age at breast and pubic hair onset in unadjusted models, but not after adjustment. CONCLUSIONS:: Greater prenatal and childhood secondhand smoke exposure were associated with earlier onset of pubic hair, but not breast, development. These exposures represent modifiable risk factors for early pubertal development that should be considered for addition to the extensive list of adverse effects from tobacco smoke.

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