TY - JOUR
T1 - Age as a modulator of inflammatory cardiovascular risk factors
AU - Erdembileg, Anuurad
AU - Byambaa, Enkhmaa
AU - Gungor, Zeynep
AU - Zhang, Wei
AU - Tracy, Russell P.
AU - Pearson, Thomas A.
AU - Kim, Kyoungmi
AU - Berglund, Lars
PY - 2011/9
Y1 - 2011/9
N2 - Objective-: Levels of acute phase reactants are affected by age. The extent to which cardiovascular risk associated with aging is due to an increase in the inflammatory burden is not known. We assessed the relationship with age of inflammatory markers, representing (1) systemic (C-reactive protein, fibrinogen, and serum amyloid-A) and (2) vascular (lipoprotein-associated phospholipase A2 and pentraxin-3) inflammation. Methods and results-: We determined lipoprotein-associated phospholipase A2 mass and activity, C-reactive protein, fibrinogen, serum amyloid-A, and pentraxin-3 levels and other cardiovascular disease risk factors in 336 whites and 224 African Americans. Levels of systemic inflammatory markers increased significantly with age in both ethnic groups (P<0.05 for all), whereas trend patterns of vascular inflammatory markers did not change significantly with age for either group. In multivariate regression models adjusting for confounding variables, age remained independently associated with a composite Z score for systemic but not vascular inflammation (β=0.250, P<0.001, and β=0.276, P<0.001, for whites and African Americans, respectively). Conclusion-: We report an increase in the systemic but not vascular inflammatory burden with age. Levels of both categories of inflammatory markers with age were similar across ethnicity after adjustment for confounders. Our results underscore the importance of age in evaluating inflammatory markers to assess cardiovascular risk.
AB - Objective-: Levels of acute phase reactants are affected by age. The extent to which cardiovascular risk associated with aging is due to an increase in the inflammatory burden is not known. We assessed the relationship with age of inflammatory markers, representing (1) systemic (C-reactive protein, fibrinogen, and serum amyloid-A) and (2) vascular (lipoprotein-associated phospholipase A2 and pentraxin-3) inflammation. Methods and results-: We determined lipoprotein-associated phospholipase A2 mass and activity, C-reactive protein, fibrinogen, serum amyloid-A, and pentraxin-3 levels and other cardiovascular disease risk factors in 336 whites and 224 African Americans. Levels of systemic inflammatory markers increased significantly with age in both ethnic groups (P<0.05 for all), whereas trend patterns of vascular inflammatory markers did not change significantly with age for either group. In multivariate regression models adjusting for confounding variables, age remained independently associated with a composite Z score for systemic but not vascular inflammation (β=0.250, P<0.001, and β=0.276, P<0.001, for whites and African Americans, respectively). Conclusion-: We report an increase in the systemic but not vascular inflammatory burden with age. Levels of both categories of inflammatory markers with age were similar across ethnicity after adjustment for confounders. Our results underscore the importance of age in evaluating inflammatory markers to assess cardiovascular risk.
KW - aging
KW - coronary artery disease
KW - epidemiology
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=80052175092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052175092&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.111.232348
DO - 10.1161/ATVBAHA.111.232348
M3 - Article
C2 - 21700927
AN - SCOPUS:80052175092
VL - 31
SP - 2151
EP - 2156
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 9
ER -