Age- and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva

David M Rocke, M. Zasloff, J. Peeper, R. B. Cohen, F. S. Kaplan

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

Using data from a survey of 44 patients who have fibrodysplasia ossificans progressiva, age- and joint-specific risks of new joint involvement were estimated using parametric and nonparametric statistical methods. Regions in which the risk of heterotopic ossification appears to remain constant with age include the neck, spine, shoulders, elbows, and ankles. Regions with apparently increasing risk include the jaw, wrists, hips, and knees. This analysis allows clinicians to estimate the risk of new involvement for any joint at any patient age, as well as the fraction of patients with uninvolved joints at any age. The variation of ossification risk by joint provides a clinically useful guide to the patterns of progression of the disease. Such a guide will help in planning for individual patient needs, as well as anticipating auxiliary social services and rehabilitation programs.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalClinical Orthopaedics and Related Research
Issue number301
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Fingerprint Dive into the research topics of 'Age- and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva'. Together they form a unique fingerprint.

  • Cite this