Abstract
In the clinical management of acute and chronic cardiac dysfunction, systemic vasodilators constitute a new approach through their reduction of elevated left ventricular wall tension during systole (ventricular afterload) by decreasing aortic impedance and/or diminishing venous return to the heart. Thus the agents may result in elevation of lowered cardiac output by reducing peripheral vascular resistance and/or in decline of increased ventricular end-diastolic volume (ventricular preload) by lowering venous tone. In addition, these agents cause concomitant reduction in myocardial oxygen requirements which is of special importance in ischemic heart disease.
Original language | English (US) |
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Pages (from-to) | 199-204 |
Number of pages | 6 |
Journal | Advances in Cardiology |
Volume | Vol.22 |
State | Published - 1977 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine