Afterload reduction in congestive heart failure

R. R. Miller, N. Awan, Ezra A Amsterdam, D. T. Mason

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In the clinical management of acute and chronic cardiac dysfunction, systemic vasodilators constitute a new approach through their reduction of elevated left ventricular wall tension during systole (ventricular afterload) by decreasing aortic impedance and/or diminishing venous return to the heart. Thus the agents may result in elevation of lowered cardiac output by reducing peripheral vascular resistance and/or in decline of increased ventricular end-diastolic volume (ventricular preload) by lowering venous tone. In addition, these agents cause concomitant reduction in myocardial oxygen requirements which is of special importance in ischemic heart disease.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalAdvances in Cardiology
StatePublished - 1977

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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