Abstract
We studied whether African-American race is associated with younger age and decreased survival time at diagnosis of interstitial lung disease (ILD).We performed a multicentre, propensity score-matched analysis of patients with an ILD diagnosis followed at five US hospitals between 2006 and 2016. African-Americans were matched with patients of other races based on a time-dependent propensity score calculated from multiple patient, physiological, diagnostic and hospital characteristics. Multivariable logistic regression models were used. All-cause mortality and hospitalisations were compared between race-stratified patient cohorts with ILD, and sensitivity analyses were performed.The study included 1640 patients with ILD, 13% of whom were African-American, followed over 5041 person-years. When compared with patients of other races, African-Americans with ILD were younger at diagnosis (56 years versus 67 years), but in the propensity-matched analyses had greater survival (hazard ratio 0.46, 95% CI 0.28-0.77; p=0.003) despite similar risk of respiratory hospitalisations (relative risk 1.04, 95% CI 0.83-1.31; p=0.709), and similar GAP-ILD (gender-age-physiology-ILD) scores at study entry. Sensitivity analyses in a separate cohort of 9503 patients with code-based ILD diagnosis demonstrated a similar association of baseline demographic characteristics with all-cause mortality.We conclude that African-Americans demonstrate a unique phenotype associated with younger age at ILD diagnosis and perhaps longer survival time.
| Original language | English (US) |
|---|---|
| Journal | The European respiratory journal |
| Volume | 51 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2018 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
African-American race and mortality in interstitial lung disease : a multicentre propensity-matched analysis. / Adegunsoye, Ayodeji; Oldham, Justin; Bellam, Shashi K.; Chung, Jonathan H.; Chung, Paul A.; Biblowitz, Kathleen M.; Montner, Steven; Lee, Cathryn; Hsu, Scully; Husain, Aliya N.; Vij, Rekha; Mutlu, Gokhan; Noth, Imre; Churpek, Matthew M.; Strek, Mary E.
In: The European respiratory journal, Vol. 51, No. 6, 01.06.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - African-American race and mortality in interstitial lung disease
T2 - a multicentre propensity-matched analysis
AU - Adegunsoye, Ayodeji
AU - Oldham, Justin
AU - Bellam, Shashi K.
AU - Chung, Jonathan H.
AU - Chung, Paul A.
AU - Biblowitz, Kathleen M.
AU - Montner, Steven
AU - Lee, Cathryn
AU - Hsu, Scully
AU - Husain, Aliya N.
AU - Vij, Rekha
AU - Mutlu, Gokhan
AU - Noth, Imre
AU - Churpek, Matthew M.
AU - Strek, Mary E.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - We studied whether African-American race is associated with younger age and decreased survival time at diagnosis of interstitial lung disease (ILD).We performed a multicentre, propensity score-matched analysis of patients with an ILD diagnosis followed at five US hospitals between 2006 and 2016. African-Americans were matched with patients of other races based on a time-dependent propensity score calculated from multiple patient, physiological, diagnostic and hospital characteristics. Multivariable logistic regression models were used. All-cause mortality and hospitalisations were compared between race-stratified patient cohorts with ILD, and sensitivity analyses were performed.The study included 1640 patients with ILD, 13% of whom were African-American, followed over 5041 person-years. When compared with patients of other races, African-Americans with ILD were younger at diagnosis (56 years versus 67 years), but in the propensity-matched analyses had greater survival (hazard ratio 0.46, 95% CI 0.28-0.77; p=0.003) despite similar risk of respiratory hospitalisations (relative risk 1.04, 95% CI 0.83-1.31; p=0.709), and similar GAP-ILD (gender-age-physiology-ILD) scores at study entry. Sensitivity analyses in a separate cohort of 9503 patients with code-based ILD diagnosis demonstrated a similar association of baseline demographic characteristics with all-cause mortality.We conclude that African-Americans demonstrate a unique phenotype associated with younger age at ILD diagnosis and perhaps longer survival time.
AB - We studied whether African-American race is associated with younger age and decreased survival time at diagnosis of interstitial lung disease (ILD).We performed a multicentre, propensity score-matched analysis of patients with an ILD diagnosis followed at five US hospitals between 2006 and 2016. African-Americans were matched with patients of other races based on a time-dependent propensity score calculated from multiple patient, physiological, diagnostic and hospital characteristics. Multivariable logistic regression models were used. All-cause mortality and hospitalisations were compared between race-stratified patient cohorts with ILD, and sensitivity analyses were performed.The study included 1640 patients with ILD, 13% of whom were African-American, followed over 5041 person-years. When compared with patients of other races, African-Americans with ILD were younger at diagnosis (56 years versus 67 years), but in the propensity-matched analyses had greater survival (hazard ratio 0.46, 95% CI 0.28-0.77; p=0.003) despite similar risk of respiratory hospitalisations (relative risk 1.04, 95% CI 0.83-1.31; p=0.709), and similar GAP-ILD (gender-age-physiology-ILD) scores at study entry. Sensitivity analyses in a separate cohort of 9503 patients with code-based ILD diagnosis demonstrated a similar association of baseline demographic characteristics with all-cause mortality.We conclude that African-Americans demonstrate a unique phenotype associated with younger age at ILD diagnosis and perhaps longer survival time.
UR - http://www.scopus.com/inward/record.url?scp=85061270858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061270858&partnerID=8YFLogxK
U2 - 10.1183/13993003.00255-2018
DO - 10.1183/13993003.00255-2018
M3 - Article
C2 - 29724923
AN - SCOPUS:85061270858
VL - 51
JO - European Respiratory Journal
JF - European Respiratory Journal
SN - 0903-1936
IS - 6
ER -