Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics

Xueting Li, Min Xue, Otto G. Raabe, Holly L. Aaron, Ellen A. Eisen, James E. Evans, Fred A. Hayes, Sumire Inaga, Abderrahmane Tagmount, Minoru Takeuchi, Chris Vulpe, Jeffrey I. Zink, Subhash H. Risbud, Kent E Pinkerton

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A highly versatile nanoplatform that couples mesoporous silica nanoparticles (MSNs) with an aerosol technology to achieve direct nanoscale delivery to the respiratory tract is described. This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, including nasal, tracheobronchial and pulmonary regions using a water-based aerosol. This delivery method was successfully tested in mice by inhalation. The MSN nanoparticles used have the potential for carrying and delivering therapeutic agents to highly specific target sites of the respiratory tract. The approach provides a critical foundation for developing therapeutic treatment protocols for a wide range of diseases where aerosol delivery to the respiratory system would be desirable. From the Clinical Editor: Delivery of drugs via the respiratory tract is an attractive route of administration. In this article, the authors described the design of mesoporous silica nanoparticles which could act as carriers for drugs. The underlying efficacy was successfully tested in a mouse model. This drug-carrier inhalation nanotechnology should potentially be useful in human clinical setting in the future.

Original languageEnglish (US)
Pages (from-to)1377-1385
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume11
Issue number6
DOIs
StatePublished - 2015

Fingerprint

Aerosols
Silicon Dioxide
Nanoparticles
Respiratory System
Silica
Drug Carriers
Inhalation
Therapeutics
Respiratory system
Nanotechnology
Clinical Protocols
Nose
Deposits
Technology
Lung
Water
Pharmaceutical Preparations

Keywords

  • Aerosol droplets
  • Mesoporous silica nanoparticles
  • Respiratory tract

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

Aerosol droplet delivery of mesoporous silica nanoparticles : A strategy for respiratory-based therapeutics. / Li, Xueting; Xue, Min; Raabe, Otto G.; Aaron, Holly L.; Eisen, Ellen A.; Evans, James E.; Hayes, Fred A.; Inaga, Sumire; Tagmount, Abderrahmane; Takeuchi, Minoru; Vulpe, Chris; Zink, Jeffrey I.; Risbud, Subhash H.; Pinkerton, Kent E.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 11, No. 6, 2015, p. 1377-1385.

Research output: Contribution to journalArticle

Li, X, Xue, M, Raabe, OG, Aaron, HL, Eisen, EA, Evans, JE, Hayes, FA, Inaga, S, Tagmount, A, Takeuchi, M, Vulpe, C, Zink, JI, Risbud, SH & Pinkerton, KE 2015, 'Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 11, no. 6, pp. 1377-1385. https://doi.org/10.1016/j.nano.2015.03.007
Li, Xueting ; Xue, Min ; Raabe, Otto G. ; Aaron, Holly L. ; Eisen, Ellen A. ; Evans, James E. ; Hayes, Fred A. ; Inaga, Sumire ; Tagmount, Abderrahmane ; Takeuchi, Minoru ; Vulpe, Chris ; Zink, Jeffrey I. ; Risbud, Subhash H. ; Pinkerton, Kent E. / Aerosol droplet delivery of mesoporous silica nanoparticles : A strategy for respiratory-based therapeutics. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2015 ; Vol. 11, No. 6. pp. 1377-1385.
@article{0df947fa083b4f2da32c46d90c9cc6ec,
title = "Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics",
abstract = "A highly versatile nanoplatform that couples mesoporous silica nanoparticles (MSNs) with an aerosol technology to achieve direct nanoscale delivery to the respiratory tract is described. This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, including nasal, tracheobronchial and pulmonary regions using a water-based aerosol. This delivery method was successfully tested in mice by inhalation. The MSN nanoparticles used have the potential for carrying and delivering therapeutic agents to highly specific target sites of the respiratory tract. The approach provides a critical foundation for developing therapeutic treatment protocols for a wide range of diseases where aerosol delivery to the respiratory system would be desirable. From the Clinical Editor: Delivery of drugs via the respiratory tract is an attractive route of administration. In this article, the authors described the design of mesoporous silica nanoparticles which could act as carriers for drugs. The underlying efficacy was successfully tested in a mouse model. This drug-carrier inhalation nanotechnology should potentially be useful in human clinical setting in the future.",
keywords = "Aerosol droplets, Mesoporous silica nanoparticles, Respiratory tract",
author = "Xueting Li and Min Xue and Raabe, {Otto G.} and Aaron, {Holly L.} and Eisen, {Ellen A.} and Evans, {James E.} and Hayes, {Fred A.} and Sumire Inaga and Abderrahmane Tagmount and Minoru Takeuchi and Chris Vulpe and Zink, {Jeffrey I.} and Risbud, {Subhash H.} and Pinkerton, {Kent E}",
year = "2015",
doi = "10.1016/j.nano.2015.03.007",
language = "English (US)",
volume = "11",
pages = "1377--1385",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Aerosol droplet delivery of mesoporous silica nanoparticles

T2 - A strategy for respiratory-based therapeutics

AU - Li, Xueting

AU - Xue, Min

AU - Raabe, Otto G.

AU - Aaron, Holly L.

AU - Eisen, Ellen A.

AU - Evans, James E.

AU - Hayes, Fred A.

AU - Inaga, Sumire

AU - Tagmount, Abderrahmane

AU - Takeuchi, Minoru

AU - Vulpe, Chris

AU - Zink, Jeffrey I.

AU - Risbud, Subhash H.

AU - Pinkerton, Kent E

PY - 2015

Y1 - 2015

N2 - A highly versatile nanoplatform that couples mesoporous silica nanoparticles (MSNs) with an aerosol technology to achieve direct nanoscale delivery to the respiratory tract is described. This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, including nasal, tracheobronchial and pulmonary regions using a water-based aerosol. This delivery method was successfully tested in mice by inhalation. The MSN nanoparticles used have the potential for carrying and delivering therapeutic agents to highly specific target sites of the respiratory tract. The approach provides a critical foundation for developing therapeutic treatment protocols for a wide range of diseases where aerosol delivery to the respiratory system would be desirable. From the Clinical Editor: Delivery of drugs via the respiratory tract is an attractive route of administration. In this article, the authors described the design of mesoporous silica nanoparticles which could act as carriers for drugs. The underlying efficacy was successfully tested in a mouse model. This drug-carrier inhalation nanotechnology should potentially be useful in human clinical setting in the future.

AB - A highly versatile nanoplatform that couples mesoporous silica nanoparticles (MSNs) with an aerosol technology to achieve direct nanoscale delivery to the respiratory tract is described. This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, including nasal, tracheobronchial and pulmonary regions using a water-based aerosol. This delivery method was successfully tested in mice by inhalation. The MSN nanoparticles used have the potential for carrying and delivering therapeutic agents to highly specific target sites of the respiratory tract. The approach provides a critical foundation for developing therapeutic treatment protocols for a wide range of diseases where aerosol delivery to the respiratory system would be desirable. From the Clinical Editor: Delivery of drugs via the respiratory tract is an attractive route of administration. In this article, the authors described the design of mesoporous silica nanoparticles which could act as carriers for drugs. The underlying efficacy was successfully tested in a mouse model. This drug-carrier inhalation nanotechnology should potentially be useful in human clinical setting in the future.

KW - Aerosol droplets

KW - Mesoporous silica nanoparticles

KW - Respiratory tract

UR - http://www.scopus.com/inward/record.url?scp=84937151867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937151867&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2015.03.007

DO - 10.1016/j.nano.2015.03.007

M3 - Article

C2 - 25819886

AN - SCOPUS:84937151867

VL - 11

SP - 1377

EP - 1385

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

IS - 6

ER -