Adverse Reactions to Vaccination. From Anaphylaxis to Autoimmunity

Laurel J Gershwin

doi:10.1016/j.cvsm.2017.10.005

Adverse Reactions to Vaccination. From Anaphylaxis to Autoimmunity

Laurel J Gershwin

Pathology, Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.

Original language	English (US)
Journal	Veterinary Clinics of North America - Small Animal Practice
DOIs	https://doi.org/10.1016/j.cvsm.2017.10.005
State	Accepted/In press - Jan 1 2017

Keywords

Anaphylaxis
Arthus reaction
Autoimmunity
IgE
Vaccine reactions

ASJC Scopus subject areas

Small Animals

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10.1016/j.cvsm.2017.10.005

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abstract = "Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.",

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AB - Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.

KW - Anaphylaxis

KW - Arthus reaction

KW - Autoimmunity

KW - IgE

KW - Vaccine reactions

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Adverse Reactions to Vaccination. From Anaphylaxis to Autoimmunity

Abstract

Keywords

ASJC Scopus subject areas

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