Abstract
Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.
| Original language | English (US) |
|---|---|
| Journal | Veterinary Clinics of North America - Small Animal Practice |
| DOIs | |
| State | Accepted/In press - Jan 1 2017 |
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Keywords
- Anaphylaxis
- Arthus reaction
- Autoimmunity
- IgE
- Vaccine reactions
ASJC Scopus subject areas
- Small Animals
Cite this
Adverse Reactions to Vaccination. From Anaphylaxis to Autoimmunity. / Gershwin, Laurel J.
In: Veterinary Clinics of North America - Small Animal Practice, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adverse Reactions to Vaccination. From Anaphylaxis to Autoimmunity
AU - Gershwin, Laurel J
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.
AB - Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.
KW - Anaphylaxis
KW - Arthus reaction
KW - Autoimmunity
KW - IgE
KW - Vaccine reactions
UR - http://www.scopus.com/inward/record.url?scp=85036526756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85036526756&partnerID=8YFLogxK
U2 - 10.1016/j.cvsm.2017.10.005
DO - 10.1016/j.cvsm.2017.10.005
M3 - Article
C2 - 29195924
AN - SCOPUS:85036526756
JO - Veterinary Clinics of North America - Small Animal Practice
JF - Veterinary Clinics of North America - Small Animal Practice
SN - 0195-5616
ER -