Adverse obstetric events are associated with significant risk of cerebral palsy

William M. Gilbert, Bryon N. Jacoby, Guibo Xing, Beate Danielsen, Lloyd H Smith

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objective: To examine adverse birth events on the development of cerebral palsy in California. Study Design: A retrospective population-based study of children with cerebral palsy (as of Nov. 30, 2006), matched to their maternal/infant delivery records (Jan. 1, 1991 to Dec. 31, 2001) was performed. Demographic data and intrapartum events were examined. Six adverse birth-related events were chosen. Children without cerebral palsy were controls. Results: There were 7242 children who had cerebral palsy (59% term) and 31.3% had 1 or more of the 6 adverse intrapartum events (12.9% in controls P < .0001). This held for both term (28.3% vs 12.7% controls) and preterm (36.8% vs 15.9%, controls) neonates (both P < .0001). Maternal (15.1% vs 6.6%) and neonatal (0.9% vs 0.1%) infection were increased in cerebral palsy cases (P < .0001). Conclusion: Almost one-third of children with cerebral palsy had at least 1 adverse birth-related event. Higher rates in the preterm group may partially explain the higher rates of cerebral palsy in this group.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
StatePublished - Oct 2010


  • birth asphyxia
  • cerebral palsy
  • uterine rupture

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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