Adverse impact of venous thromboembolism on patients with cancer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Venous thromboembolism (VTE) is a common complication of malignancy. This is related to the underlying cancer and thrombogenic effects of various therapies. Compared with VTE in patients without malignancies, cancer-associated thrombosis is associated with increased mortality, recurrence, and bleeding while on anticoagulants. These worse outcomes are due to a complex interplay between the underlying cancer, host response, antitumor therapies, and interactions between anticoagulants and cancer drugs. Primary prevention of VTE may decrease morbidity and possibly even improve cancer-related survival, but studies to date have not clearly identified a patient population that might be of most benefit nor consistently shown a survival benefit to anticoagulation.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalSeminars in Thrombosis and Hemostasis
Volume40
Issue number3
DOIs
StatePublished - 2014

Keywords

  • anticoagulation
  • bleeding
  • cancer
  • chemotherapy
  • survival
  • venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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