Adverse events after screening and follow-up colonoscopy

Carolyn M. Rutter, Eric Johnson, Diana L Miglioretti, Margaret T. Mandelson, John Inadomi, Diana S M Buist

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: We provide new information about how the risk of adverse events following colonoscopy varies by age and indication (screening vs. follow-up performed to evaluate a positive result from another screening modality). Methods: We constructed a retrospective cohort comprised of 43,456 individuals aged 40-85 years enrolled in a large integrated healthcare organization in Washington State who underwent outpatient colonoscopy between 1994 and 2009. We calculated rates of serious adverse events (perforation, hemorrhage, and acute diverticulitis) in the 30 days following colonoscopy and compared rates using log-binomial regression models. Results: We observed 4.7 serious adverse events per 1,000 screening colonoscopies and 6.8 per 1,000 follow-up colonoscopies. Polypectomy increased the rate of serious adverse events (relative rate [RR], 2.64; 95% confidence interval [CI], 1.97-3.56). Older age was associated with increased risk of serious adverse events, after adjusting for polypectomy, gender, and indication. Compared to individuals aged 50-64 years, risk was elevated for those aged 65-74 (RR, 1.93; 95% CI, 1.40-2.65) and 75-85 (RR, 3.21; 95% CI 2.14-4.86). We observed similar age effects in individuals with and without significant comorbid conditions. Conclusions: The risks of serious adverse events following colonoscopy performed as part of screening are low but increase with age and are more likely after polypectomy.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalCancer Causes and Control
Volume23
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

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Colonoscopy
Confidence Intervals
Diverticulitis
Statistical Models
Outpatients
Hemorrhage
Delivery of Health Care

Keywords

  • Age trends
  • Colorectal cancer screening
  • Comorbidity
  • Polypectomy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Rutter, C. M., Johnson, E., Miglioretti, D. L., Mandelson, M. T., Inadomi, J., & Buist, D. S. M. (2012). Adverse events after screening and follow-up colonoscopy. Cancer Causes and Control, 23(2), 289-296. https://doi.org/10.1007/s10552-011-9878-5

Adverse events after screening and follow-up colonoscopy. / Rutter, Carolyn M.; Johnson, Eric; Miglioretti, Diana L; Mandelson, Margaret T.; Inadomi, John; Buist, Diana S M.

In: Cancer Causes and Control, Vol. 23, No. 2, 02.2012, p. 289-296.

Research output: Contribution to journalArticle

Rutter, CM, Johnson, E, Miglioretti, DL, Mandelson, MT, Inadomi, J & Buist, DSM 2012, 'Adverse events after screening and follow-up colonoscopy', Cancer Causes and Control, vol. 23, no. 2, pp. 289-296. https://doi.org/10.1007/s10552-011-9878-5
Rutter, Carolyn M. ; Johnson, Eric ; Miglioretti, Diana L ; Mandelson, Margaret T. ; Inadomi, John ; Buist, Diana S M. / Adverse events after screening and follow-up colonoscopy. In: Cancer Causes and Control. 2012 ; Vol. 23, No. 2. pp. 289-296.
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