Adverse effects of a 10-day course of ibuprofen in Holstein calves

P. Walsh, F. R. Carvallo Chaigneau, M. Anderson, N. Behrens, H. Mceligot, B. Gunnarson, L. J. Gershwin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for various conditions in cattle. Ibuprofen is an inexpensive short-acting NSAID and is readily available in liquid formulation for administration to bottle-fed calves. We compared the adverse effects of a 10-day course of ibuprofen and placebo in 16 five- to six-week-old Holstein bull calves that were being treated for experimentally induced bovine respiratory syncytial virus infection. Ibuprofen was administered as a liquid in milk replacer at 30 mg/kg divided three times daily. We found an increased prevalence of abomasal ulceration 5 of 8 in the ibuprofen compared to placebo group 2 of 6 (P = NS). There was one (1 of 8) case of mild interstitial nephritis in the ibuprofen and none (0 of 8) in the placebo group (P = NS). Renal function as measured by serum BUN and creatinine levels was not different between groups; no animal demonstrated an increase in creatinine.

Original languageEnglish (US)
JournalJournal of Veterinary Pharmacology and Therapeutics
StateAccepted/In press - 2016

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)


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