Adverse effect of inhalational anesthetics on the developing brain

Mike Wang, John H. Zhang, Richard Lee Applegate

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


We did a PubMed search and summarized studies on the potential adverse effect of anesthetics especially neurotoxicity in the developing brain, so named anesthesia-induced developmental neurotoxicity. Even though many experimental studies using animal models indicated some adverse effect of anesthetics, more evidence is needed before a recommendation can be made to change the way those anesthetics are used in the pediatric population. Two large clinical trials are underway and may provide insight to the potential human neurotoxic effect of anesthetics.

Original languageEnglish (US)
Article number2
JournalMedical Gas Research
Issue number1
StatePublished - Feb 14 2014
Externally publishedYes


  • Anesthetics
  • Developing brain
  • Neurotoxicity

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Anesthesiology and Pain Medicine


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