Advancing nasal reconstructive surgery: The application of tissue engineering technology

Adelola Oseni, Claire Crowley, Mark Lowdell, Martin Birchall, Peter E. Butler, Alexander M. Seifalian

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cartilage tissue engineering is a rapidly progressing area of regenerative medicine with advances in cell biology and scaffold engineering constantly being investigated. Many groups are now capable of making neocartilage constructs with some level of morphological, biochemical, and histological likeness to native human cartilage tissues. The application of this useful technology in articular cartilage repair is well described in the literature; however, few studies have evaluated its application in head and neck reconstruction. Although there are many studies on auricular cartilage tissue engineering, there are few studies regarding cartilage tissue engineering for complex nasal reconstruction. This study therefore highlighted the challenges involved with nasal reconstruction, with special focus on nasal cartilage tissue, and examined how advancements made in cartilage tissue engineering research could be applied to improve the clinical outcomes of total nasal reconstructive surgery.

Original languageEnglish (US)
Pages (from-to)757-768
Number of pages12
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume6
Issue number10
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Reconstructive Surgical Procedures
Nasal Surgical Procedures
Engineering technology
Cartilage
Tissue Engineering
Tissue engineering
Surgery
Technology
Nose
Nasal Cartilages
Ear Cartilage
Regenerative Medicine
Articular Cartilage
Population Groups
Cell Biology
Cytology
Tissue
Neck
Head
Engineering research

Keywords

  • Biomaterials
  • Nanotechnology
  • Nasal reconstructive surgery
  • Rhinoplasty
  • Scaffold
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

Cite this

Advancing nasal reconstructive surgery : The application of tissue engineering technology. / Oseni, Adelola; Crowley, Claire; Lowdell, Mark; Birchall, Martin; Butler, Peter E.; Seifalian, Alexander M.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 6, No. 10, 11.2012, p. 757-768.

Research output: Contribution to journalArticle

Oseni, Adelola ; Crowley, Claire ; Lowdell, Mark ; Birchall, Martin ; Butler, Peter E. ; Seifalian, Alexander M. / Advancing nasal reconstructive surgery : The application of tissue engineering technology. In: Journal of Tissue Engineering and Regenerative Medicine. 2012 ; Vol. 6, No. 10. pp. 757-768.
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