Advancing nasal reconstructive surgery: The application of tissue engineering technology

Adelola Oseni, Claire Crowley, Mark Lowdell, Martin Birchall, Peter E. Butler, Alexander M. Seifalian

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Cartilage tissue engineering is a rapidly progressing area of regenerative medicine with advances in cell biology and scaffold engineering constantly being investigated. Many groups are now capable of making neocartilage constructs with some level of morphological, biochemical, and histological likeness to native human cartilage tissues. The application of this useful technology in articular cartilage repair is well described in the literature; however, few studies have evaluated its application in head and neck reconstruction. Although there are many studies on auricular cartilage tissue engineering, there are few studies regarding cartilage tissue engineering for complex nasal reconstruction. This study therefore highlighted the challenges involved with nasal reconstruction, with special focus on nasal cartilage tissue, and examined how advancements made in cartilage tissue engineering research could be applied to improve the clinical outcomes of total nasal reconstructive surgery.

Original languageEnglish (US)
Pages (from-to)757-768
Number of pages12
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number10
StatePublished - Nov 2012
Externally publishedYes


  • Biomaterials
  • Nanotechnology
  • Nasal reconstructive surgery
  • Rhinoplasty
  • Scaffold
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials


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