Advances in the genetics of cerebrovascular disease and stroke

G. J. Hademenos, M. J. Alberts, I. Awad, M. Mayberg, T. Shephard, A. Jagoda, Richard E Latchaw, H. W. Todd, K. Viste, R. Starke, M. St. John Girgus, M. Walker, J. Marler, M. Emr, N. Hart

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

MEDLINE searches identified epidemiologic, experimental, and clinical studies on the genetics of cerebrovascular disease and stroke, including the following topics: genetic epidemiology of stroke; genetics of systemic disorders that cause ischemic stroke, including coagulation disorders, connective tissue disorders, vasculopathies, metabolic disorders, and disorders of unknown etiology; and genetics of systemic disorders that cause hemorrhagic stroke. Recent discoveries in stroke genetics involve the genetic basis of monogenic disorders such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and sickle cell disease. Reproducing similar advances in other forms of cerebrovascular disease and stroke will be more difficult because their inheritance is complex, multigenic, and heterogeneous. However, the future is promising with the application of molecular genetic approaches such as linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses as well as the transmission/disequilibrium test - a statistical method for detection of linkage between a marker and a disease-susceptibility locus.

Original languageEnglish (US)
Pages (from-to)997-1008
Number of pages12
JournalNeurology
Volume56
Issue number8
StatePublished - Apr 24 2001
Externally publishedYes

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Cerebrovascular Disorders
Inborn Genetic Diseases
Stroke
CADASIL
Molecular Epidemiology
Disease Susceptibility
Sickle Cell Anemia
MEDLINE
Connective Tissue
Epidemiologic Studies
Molecular Biology
Alleles

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hademenos, G. J., Alberts, M. J., Awad, I., Mayberg, M., Shephard, T., Jagoda, A., ... Hart, N. (2001). Advances in the genetics of cerebrovascular disease and stroke. Neurology, 56(8), 997-1008.

Advances in the genetics of cerebrovascular disease and stroke. / Hademenos, G. J.; Alberts, M. J.; Awad, I.; Mayberg, M.; Shephard, T.; Jagoda, A.; Latchaw, Richard E; Todd, H. W.; Viste, K.; Starke, R.; St. John Girgus, M.; Walker, M.; Marler, J.; Emr, M.; Hart, N.

In: Neurology, Vol. 56, No. 8, 24.04.2001, p. 997-1008.

Research output: Contribution to journalArticle

Hademenos, GJ, Alberts, MJ, Awad, I, Mayberg, M, Shephard, T, Jagoda, A, Latchaw, RE, Todd, HW, Viste, K, Starke, R, St. John Girgus, M, Walker, M, Marler, J, Emr, M & Hart, N 2001, 'Advances in the genetics of cerebrovascular disease and stroke', Neurology, vol. 56, no. 8, pp. 997-1008.
Hademenos GJ, Alberts MJ, Awad I, Mayberg M, Shephard T, Jagoda A et al. Advances in the genetics of cerebrovascular disease and stroke. Neurology. 2001 Apr 24;56(8):997-1008.
Hademenos, G. J. ; Alberts, M. J. ; Awad, I. ; Mayberg, M. ; Shephard, T. ; Jagoda, A. ; Latchaw, Richard E ; Todd, H. W. ; Viste, K. ; Starke, R. ; St. John Girgus, M. ; Walker, M. ; Marler, J. ; Emr, M. ; Hart, N. / Advances in the genetics of cerebrovascular disease and stroke. In: Neurology. 2001 ; Vol. 56, No. 8. pp. 997-1008.
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