Abstract
Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatta) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.
| Original language | English (US) |
|---|---|
| Journal | Experimental Neurology |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Animal model
- Autism spectrum disorder
- Preclinical
- Rhesus monkey
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
Cite this
Advances in nonhuman primate models of autism : Integrating neuroscience and behavior. / Bauman, Melissa D; Schumann, Cynthia.
In: Experimental Neurology, 2017.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Advances in nonhuman primate models of autism
T2 - Integrating neuroscience and behavior
AU - Bauman, Melissa D
AU - Schumann, Cynthia
PY - 2017
Y1 - 2017
N2 - Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatta) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.
AB - Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatta) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.
KW - Animal model
KW - Autism spectrum disorder
KW - Preclinical
KW - Rhesus monkey
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UR - http://www.scopus.com/inward/citedby.url?scp=85029406230&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2017.07.021
DO - 10.1016/j.expneurol.2017.07.021
M3 - Article
C2 - 28774750
AN - SCOPUS:85029406230
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
ER -