Advances in nonhuman primate models of autism: Integrating neuroscience and behavior

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatta) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.

Original languageEnglish (US)
JournalExperimental Neurology
DOIs
StateAccepted/In press - 2017

Fingerprint

Neurosciences
Autistic Disorder
Primates
Macaca mulatta
Neurobiology
Brain Diseases
Zebrafish
Research
Drosophila
Animal Models
Outcome Assessment (Health Care)
Autism Spectrum Disorder
Brain
Therapeutics

Keywords

  • Animal model
  • Autism spectrum disorder
  • Preclinical
  • Rhesus monkey

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

@article{8945eb1749654649a3c23246f243292d,
title = "Advances in nonhuman primate models of autism: Integrating neuroscience and behavior",
abstract = "Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatta) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.",
keywords = "Animal model, Autism spectrum disorder, Preclinical, Rhesus monkey",
author = "Bauman, {Melissa D} and Cynthia Schumann",
year = "2017",
doi = "10.1016/j.expneurol.2017.07.021",
language = "English (US)",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Advances in nonhuman primate models of autism

T2 - Integrating neuroscience and behavior

AU - Bauman, Melissa D

AU - Schumann, Cynthia

PY - 2017

Y1 - 2017

N2 - Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatta) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.

AB - Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatta) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.

KW - Animal model

KW - Autism spectrum disorder

KW - Preclinical

KW - Rhesus monkey

UR - http://www.scopus.com/inward/record.url?scp=85029406230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029406230&partnerID=8YFLogxK

U2 - 10.1016/j.expneurol.2017.07.021

DO - 10.1016/j.expneurol.2017.07.021

M3 - Article

C2 - 28774750

AN - SCOPUS:85029406230

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

ER -