Advances in IDH mutation in glioma

Yan Gao, Wenbin Deng, Wenrong Gong, Wenjing Zhang

Research output: Contribution to journalReview article

Abstract

Isocitrate dehydrogenase (IDH) is a key enzyme in the tricarboxylic acid cycle, catalyzing the conversion of isocitric acid to α-ketoglutaric acid (α-KG), using nicotinamide adenine dinucleotide (NAD+)/ nicotinamide adenine dinucleotide phosphate (NADP+) as its cofactor to produce NADH/NADPH. It has been recognized that more than 75% of low grade gliomas (WHO grade II and III) and 90% of secondary glioblastoma multiforme carry IDH gene mutation, with R132H mutation being predominant. IDH mutation may modulate epigenetic characteristics, reprogram cell metabolism, and perturb redox homeostasis of gliomas. Targeted inhibition of mutant IDH in glioma can suppress tumor progression and give birth to the novel anticancer medicines.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalTumor
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Glioma
  • Isocitrate degydrogenase
  • Mutation
  • Oxidation-reduction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

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