Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics

Baitang Ning, Dianke Yu, Aiming Yu

Research output: Contribution to journalReview article

Abstract

Accumulating evidence has demonstrated that genome-derived noncoding RNAs (ncRNAs) play important roles in modulating inter-individual variations observed in drug metabolism and disposition by controlling the expression of genes coding drug metabolizing enzymes and transporters (DMETs) and relevant nuclear receptors (NRs). With the understanding of novel ncRNA regulatory mechanisms and significance in the control of disease initiation and progression, RNA-based therapies are under active investigation that may expand the druggable targets from conventional proteins to RNAs and the genome for the treatment of human diseases. Herein we provide an overview of research strategies, approaches and their limitations in biochemical and pharmacological studies pertaining to ncRNA functions in the regulation of drug and nutrient metabolism and disposition, and discussion on the promise and challenges in developing RNA therapeutics.

Original languageEnglish (US)
Article number113638
JournalBiochemical Pharmacology
Volume169
DOIs
StatePublished - Nov 1 2019

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Keywords

  • Bioengineered RNA
  • Drug development
  • Drug metabolizing enzymes and transporters
  • Noncoding RNA
  • Pharmacoepigenetics
  • RNA therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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