Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering

Ganesh C. Ingavle, Jonathan K Leach

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Polymeric nanofibers have potential as tissue engineering scaffolds, as they mimic the nanoscale properties and structural characteristics of native extracellular matrix (ECM). Nanofibers composed of natural and synthetic polymers, biomimetic composites, ceramics, and metals have been fabricated by electrospinning for various tissue engineering applications. The inherent advantages of electrospinning nanofibers include the generation of substrata with high surface area-to-volume ratios, the capacity to precisely control material and mechanical properties, and a tendency for cellular in-growth due to interconnectivity within the pores. Furthermore, the electrospinning process affords the opportunity to engineer scaffolds with micro- to nanoscale topography similar to the natural ECM. This review describes the fundamental aspects of the electrospinning process when applied to spinnable natural and synthetic polymers; particularly, those parameters that influence fiber geometry, morphology, mesh porosity, and scaffold mechanical properties. We describe cellular responses to fiber morphology achieved by varying processing parameters and highlight successful applications of electrospun nanofibrous scaffolds when used to tissue engineer bone, skin, and vascular grafts.

Original languageEnglish (US)
Pages (from-to)277-293
Number of pages17
JournalTissue Engineering - Part B: Reviews
Volume20
Issue number4
DOIs
StatePublished - Aug 1 2014

Fingerprint

Nanofibers
Electrospinning
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Extracellular Matrix
Polymers
Scaffolds
Tissue Scaffolds
Biomimetics
Porosity
Ceramics
Engineers
Mechanical properties
Blood Vessels
Fibers
Bioelectric potentials
Metals
Grafts
Topography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering
  • Biochemistry
  • Medicine(all)

Cite this

Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering. / Ingavle, Ganesh C.; Leach, Jonathan K.

In: Tissue Engineering - Part B: Reviews, Vol. 20, No. 4, 01.08.2014, p. 277-293.

Research output: Contribution to journalArticle

Ingavle, Ganesh C. ; Leach, Jonathan K. / Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering. In: Tissue Engineering - Part B: Reviews. 2014 ; Vol. 20, No. 4. pp. 277-293.
@article{1c18c04187714abd92f0cc2d66006228,
title = "Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering",
abstract = "Polymeric nanofibers have potential as tissue engineering scaffolds, as they mimic the nanoscale properties and structural characteristics of native extracellular matrix (ECM). Nanofibers composed of natural and synthetic polymers, biomimetic composites, ceramics, and metals have been fabricated by electrospinning for various tissue engineering applications. The inherent advantages of electrospinning nanofibers include the generation of substrata with high surface area-to-volume ratios, the capacity to precisely control material and mechanical properties, and a tendency for cellular in-growth due to interconnectivity within the pores. Furthermore, the electrospinning process affords the opportunity to engineer scaffolds with micro- to nanoscale topography similar to the natural ECM. This review describes the fundamental aspects of the electrospinning process when applied to spinnable natural and synthetic polymers; particularly, those parameters that influence fiber geometry, morphology, mesh porosity, and scaffold mechanical properties. We describe cellular responses to fiber morphology achieved by varying processing parameters and highlight successful applications of electrospun nanofibrous scaffolds when used to tissue engineer bone, skin, and vascular grafts.",
author = "Ingavle, {Ganesh C.} and Leach, {Jonathan K}",
year = "2014",
month = "8",
day = "1",
doi = "10.1089/ten.teb.2013.0276",
language = "English (US)",
volume = "20",
pages = "277--293",
journal = "Tissue Engineering - Part B: Reviews",
issn = "1937-3368",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering

AU - Ingavle, Ganesh C.

AU - Leach, Jonathan K

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Polymeric nanofibers have potential as tissue engineering scaffolds, as they mimic the nanoscale properties and structural characteristics of native extracellular matrix (ECM). Nanofibers composed of natural and synthetic polymers, biomimetic composites, ceramics, and metals have been fabricated by electrospinning for various tissue engineering applications. The inherent advantages of electrospinning nanofibers include the generation of substrata with high surface area-to-volume ratios, the capacity to precisely control material and mechanical properties, and a tendency for cellular in-growth due to interconnectivity within the pores. Furthermore, the electrospinning process affords the opportunity to engineer scaffolds with micro- to nanoscale topography similar to the natural ECM. This review describes the fundamental aspects of the electrospinning process when applied to spinnable natural and synthetic polymers; particularly, those parameters that influence fiber geometry, morphology, mesh porosity, and scaffold mechanical properties. We describe cellular responses to fiber morphology achieved by varying processing parameters and highlight successful applications of electrospun nanofibrous scaffolds when used to tissue engineer bone, skin, and vascular grafts.

AB - Polymeric nanofibers have potential as tissue engineering scaffolds, as they mimic the nanoscale properties and structural characteristics of native extracellular matrix (ECM). Nanofibers composed of natural and synthetic polymers, biomimetic composites, ceramics, and metals have been fabricated by electrospinning for various tissue engineering applications. The inherent advantages of electrospinning nanofibers include the generation of substrata with high surface area-to-volume ratios, the capacity to precisely control material and mechanical properties, and a tendency for cellular in-growth due to interconnectivity within the pores. Furthermore, the electrospinning process affords the opportunity to engineer scaffolds with micro- to nanoscale topography similar to the natural ECM. This review describes the fundamental aspects of the electrospinning process when applied to spinnable natural and synthetic polymers; particularly, those parameters that influence fiber geometry, morphology, mesh porosity, and scaffold mechanical properties. We describe cellular responses to fiber morphology achieved by varying processing parameters and highlight successful applications of electrospun nanofibrous scaffolds when used to tissue engineer bone, skin, and vascular grafts.

UR - http://www.scopus.com/inward/record.url?scp=84905563192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905563192&partnerID=8YFLogxK

U2 - 10.1089/ten.teb.2013.0276

DO - 10.1089/ten.teb.2013.0276

M3 - Article

C2 - 24004443

AN - SCOPUS:84905563192

VL - 20

SP - 277

EP - 293

JO - Tissue Engineering - Part B: Reviews

JF - Tissue Engineering - Part B: Reviews

SN - 1937-3368

IS - 4

ER -