Advanced retinal imaging and ocular parameters of the rhesus macaque eye

Kira H. Lin, Tu Tran, Soohyun Kim, Sangwan Park, J. Timothy Stout, Rui Chen, Jeffrey Rogers, Glenn Yiu, Sara Thomasy, Ala Moshiri

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: To determine the range of normal ocular biometry and perform advanced retinal imaging and functional assessment of the rhesus macaque eye. Methods: We performed ocular phenol typing on rhesus macaques at the California National Primate Research Center. This process consisted of anterior and posterior segment eye examination by ophthalmologists, advanced retinal imaging, and functional retinal electrophysiology. Results: Full eye examinations were performed on 142 animals, consisting of pupillary light reflex, tonometry, external examination and photography, anterior slit lamp examination, and posterior segment examination by indirect ophthalmoscopy. Ages of the rhesus macaques ranged from0.7 to 29 years (mean, 16.4±7.5 years). Anterior segment measurements such as intraocular pressure (n = 142), corneal thickness (n = 84), lens thickness (n=114), and axial length (n=114) were acquired. Advanced retinal imaging in the form of fundus photography (n = 78), optical coherence tomography (n = 60), and quantitative auto fluorescence (n = 44) was obtained. Electroretinography (n = 75) was used to assay retinal function. Quantitative analyses of the macular structure, retinal layer segmentation, and rod and cone photoreceptor electrical responses are reported. Quantitative assessments were made and variations between sexes were analyzed to compare with established sex changes in human eyes. Conclusions: The rhesus macaque has an ocular structure and function very similar to that of the human eye. In particular macular structure and retinal function is very similar to humans, making this species particularly useful for the study of macular biology and development of therapies for cone photoreceptor disorders. Translational Relevance: Rhesus macaques are an ideal model for future vision science studies of human eye diseases.

Original languageEnglish (US)
Article number7
JournalTranslational Vision Science and Technology
Issue number6
StatePublished - 2021


  • Functional parameters
  • Imaging
  • Nonhuman primate
  • Ocular parameters
  • Rhesus macaque

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology


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