Adrenocorticotropic effects of a synthetic polypeptide alpha 1-24 corticotropin in normal dogs

Edward C Feldman, J. B. Tyrrell

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

As a short test of canine adrenocortical reserve, plasma cortisol values were determined after a single intramuscular injection of 0.25 mg of a synthetic polypeptide (alpha 1-24 ACTH). This synthetic polypeptide has steroidogenic activity equivalent to natural corticotropin. The synthetic polypeptide was preferable to the natural hormone because of its purity, transient action, and the inherent simplicity of using a standard dose for any sized animal. Since the test requires only 2 venipunctures and 1 hr of total time, it is suitable for use in outpatients as well as hospitalized cases. In 21 normal dogs, the mean plasma cortisol level rose from 8.33 to 26.2 μg/100 ml. This is a significant elevation with a p of less than 0.001 when comparing the baseline plasma cortisol levels to the poststimulation plasma cortisol levels. The test appears to be reasonably reproducible, since individual increases in plasma cortisol levels, with stimulation from the resting plane, varied from 11.0 to 24.8 μg/100 ml. This test should be of value as a diagnostic tool in the evaluation of animals with possible adrenocortical dysfunction.

Original languageEnglish (US)
Pages (from-to)494-499
Number of pages6
JournalJournal of the American Animal Hospital Association
Volume13
Issue number4
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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